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Synchronous Bilateral RCC Is Associated With Poor Recurrence-Free Survival Compared With Unilateral RCC: A
Jung Kwon Kim1, Hakmin Lee1, Jong Jin Oh1
1Department of Urology, Seoul National University Bundang Hospital, Seongnam, Korea.
Clinical Genitourinary Cancer
|March 30, 2019
Summary
Patients with bilateral renal cell carcinoma (RCC) have worse recurrence-free survival than those with unilateral RCC. Synchronous bilateral RCC presents more adverse features than metachronous bilateral RCC.
Area of Science:
- Oncology
- Urology
- Surgical Oncology
Background:
- Bilateral cancers in paired organs require understanding for effective treatment and follow-up.
- Limited studies compare survival outcomes between unilateral and bilateral renal cell carcinoma (RCC).
Purpose of the Study:
- To evaluate survival outcomes in patients with unilateral versus bilateral renal cell carcinoma (RCC) after surgery.
- To compare survival outcomes between synchronous and metachronous bilateral RCC.
Main Methods:
- Analysis of clinical data from 2169 unilateral RCC and 44 bilateral RCC patients.
- Propensity score matching analysis for comparative assessment of unilateral and bilateral RCC groups.
- Subgroup analysis comparing synchronous and metachronous bilateral RCC.
Main Results:
- Bilateral RCC group showed significantly decreased 5-year recurrence-free survival (RFS) compared to the unilateral group (82.6% vs. 94.3%).
- Metachronous RCC group had smaller mean tumor size and more favorable pathologic T stage than synchronous RCC.
- Synchronous RCC group had significantly decreased 5-year RFS compared to metachronous RCC (74.7% vs. 92.9%).
Conclusions:
- Bilateral renal cell carcinoma is associated with significantly decreased 5-year recurrence-free survival compared to unilateral disease.
- Synchronous bilateral RCC exhibits more adverse pathological features and poorer survival outcomes than metachronous bilateral RCC.
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