Ganglioglioma with Cerebrospinal Fluid Rhinorrhea: A Rare Presentation

Gangliogliomas are low-grade gliomas, and patients generally present with seizures. Gangliogliomas commonly occur in the temporal lobe and predominantly occur in children. Malignant progression is rare.

A 26-year-old woman presented with a history of seizures since childhood and cerebrospinal fluid rhinorrhea for the past 6 months. Generally, patients with gangliogliomas seek early medical attention, as they present with dramatic complex partial seizures. This patient experienced seizures for 10 years and never sought medical attention during this time. She did not present for medical evaluation until she developed cerebrospinal fluid rhinorrhea.

This case gave us an opportunity to learn the natural history of ganglioglioma, although clinical presentations vary according to tumor location. This is the first case report to our knowledge of a patient with ganglioglioma presenting with cerebrospinal fluid rhinorrhea.