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Phosphoinositide phosphatases in cancer cell dynamics-Beyond PI3K and PTEN

Takeshi Ijuin1

  • 1Division of Biochemistry, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki, Chu-o, Kobe 650-0017, Japan.

Seminars in Cancer Biology
|March 30, 2019
PubMed

Insights

Phosphoinositides regulate cell signaling, but their hyperactivation fuels cancer. This review explores how phosphoinositide phosphatases impact cancer cell dynamics by altering phosphoinositide levels.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • Phosphoinositides are critical lipids regulating intracellular signaling pathways.
  • The phosphatidylinositol-3,4,5-trisphosphate/Akt pathway is vital for cell growth, migration, and polarity.
  • Hyperactivation of this pathway is linked to cancer development and malignancy.

Purpose of the Study:

  • To review the role of phosphoinositide phosphatases in cancer cell signaling.
  • To discuss how enzyme activity affects phosphoinositide levels in cancer.
  • To highlight the impact on cancer cell dynamics.

Main Methods:

  • Literature review of phosphoinositide signaling in cancer.
  • Analysis of phosphoinositide phosphatase activity and its consequences.
  • Focus on cancer cell dynamics, including cytoskeletal rearrangement and organelle organization.

Main Results:

  • Aberrant phosphoinositide phosphatase activity alters phosphoinositide levels in cancer cells.
  • These alterations impact key cancer cell behaviors like proliferation and migration.
  • Dysregulated signaling contributes to oncogenic transformation and malignancy.

Conclusions:

  • Phosphoinositide phosphatases are crucial regulators of cancer cell dynamics.
  • Targeting these enzymes may offer therapeutic strategies for cancer.
  • Understanding their role is key to deciphering cancer cell behavior.
Keywords:
Cell migrationCell polarityFocal adhesionInvadopodiaPI(3,4)P(2)PIP(3)Phosphoinositide phosphatase

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