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Diabetic cardiomyopathy - A comprehensive updated review
Ghulam Murtaza1, Hafeez Ul Hassan Virk2, Muhammad Khalid1
1Department of Internal Medicine, Division of Cardiology, East Tennessee State University, Johnson City, TN, USA.
Progress in Cardiovascular Diseases
|March 30, 2019
Summary
Diabetic cardiomyopathy (DCM) is a heart condition caused by diabetes, increasing heart failure risk. This review covers DCM's molecular causes, diagnostic tools, and new therapeutic strategies.
Area of Science:
- Cardiology
- Endocrinology
- Molecular Medicine
Background:
- Diabetes mellitus is a significant risk factor for heart failure.
- Diabetic Cardiomyopathy (DCM) is a distinct clinical entity characterized by cardiac dysfunction in diabetic patients, independent of other cardiovascular risk factors.
- Recent research has focused on understanding the molecular basis and structural changes in DCM.
Purpose of the Study:
- To review recent advancements in understanding the molecular mechanisms of Diabetic Cardiomyopathy (DCM).
- To summarize novel therapeutic approaches for the prevention and treatment of DCM.
- To outline current diagnostic modalities, screening tests, and treatment options for DCM.
Main Methods:
- Literature review of recent scientific publications on Diabetic Cardiomyopathy.
- Synthesis of information on molecular abnormalities, structural changes, and functional alterations in DCM.
- Compilation of data on diagnostic tools and therapeutic strategies.
Main Results:
- DCM involves complex molecular abnormalities contributing to cardiac dysfunction.
- Several novel therapeutic targets and strategies are emerging for DCM.
- Early diagnosis and timely intervention are crucial for managing DCM.
Conclusions:
- A deeper understanding of DCM's molecular underpinnings is essential for developing effective treatments.
- Advancements in diagnostics and therapeutics offer hope for improved patient outcomes in DCM.
- This review provides a comprehensive overview for clinicians and researchers in the field of Diabetic Cardiomyopathy.
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