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Bioactive polymeric formulations for wound healing.

Ahmed A Nada1,2,3, Michael R Arul3, Daisy M Ramos3

  • 1Pretreatment & Finishing of Cellulose Based Textiles Dept., National Research Centre, Dokki, Giza, Egypt.

Polymers for Advanced Technologies
|March 30, 2019
PubMed
Summary

This study developed a ricinoleic acid (RA) liposomal hydrogel for wound healing. The novel formulation demonstrated accelerated wound contraction and normal skin layer regeneration in rats.

Keywords:
chitosan hydrogelliposomesricinoleic acidtopical applicationwound healing

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Area of Science:

  • Biomaterials Science
  • Wound Healing Research
  • Drug Delivery Systems

Background:

  • Ricinoleic acid (RA) exhibits analgesic and anti-inflammatory properties, suggesting potential for wound healing.
  • Topical drug delivery systems are crucial for effective wound management.
  • Liposomes and hydrogels offer advanced platforms for controlled drug release.

Purpose of the Study:

  • To synthesize and characterize ricinoleic acid (RA) liposomes incorporated into a chitosan-based hydrogel for topical wound healing.
  • To optimize hydrogel properties, including gelation time, water content, and mechanical strength, for controlled RA release.
  • To evaluate the in vitro and in vivo efficacy of the RA-liposomal hydrogel in promoting wound healing.

Main Methods:

  • Lecithin liposomes encapsulating RA were prepared and integrated into a chitosan solution.
  • The chitosan/liposome mixture was cross-linked with dialdehyde β-cyclodextrin (Di-β-CD) under varied conditions.
  • Hydrogel characterization involved spectroscopy, microscopy, swelling studies, mechanical testing, and in vitro/in vivo wound healing assays.

Main Results:

  • Hydrogel cross-linking was confirmed, with formulation parameters influencing matrix swelling, mechanical properties, and morphology.
  • Higher cross-linking density resulted in reduced water uptake and slower RA release.
  • Optimized formulations achieved an initial burst release followed by sustained release of 80% RA over 48 hours.
  • In vivo studies showed significantly higher wound contraction rates compared to a commercial cream.
  • Histopathological analysis indicated accelerated and normal healing of skin layers.

Conclusions:

  • The developed RA-liposomal chitosan hydrogel is a promising topical formulation for effective wound healing.
  • Controlled release of RA from the hydrogel enhances wound contraction and promotes normal tissue regeneration.
  • Further investigation into RA concentration is needed to avoid cytotoxicity while maximizing therapeutic benefits.