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Cefquinome-Loaded Microsphere Formulations in Protection against Pneumonia with Klebsiella pneumonia Infection and

Shaoqi Qu1,2, Cunchun Dai1,2, Fenfang Yang1,2

  • 1College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao, 266109, China.

Pharmaceutical Research
|March 30, 2019
PubMed
Abstract

Insights

Cefquinome (CEQ)-loaded poly lactic-co-glycolic acid (PLGA) microspheres (CEQ-PLGA-MS) demonstrated superior efficacy over standard cefquinome injection (CEQ-INJ) in treating Klebsiella pneumonia lung infections in rats. This novel microsphere formulation significantly reduced bacterial load and inflammation.

Area of Science:

  • Pharmacology
  • Infectious Diseases
  • Biomaterials

Background:

  • Klebsiella pneumoniae is a significant pathogen causing lung infections.
  • Effective treatment strategies for bacterial pneumonia are crucial.
  • Novel drug delivery systems can enhance therapeutic outcomes.

Purpose of the Study:

  • To compare the in vivo antimicrobial activity of cefquinome-loaded poly lactic-co-glycolic acid microspheres (CEQ-PLGA-MS) against cefquinome injection (CEQ-INJ).
  • To evaluate the efficacy of CEQ-PLGA-MS in a rat model of Klebsiella pneumoniae lung infection.

Main Methods:

  • A rat model of Klebsiella pneumoniae lung infection was established.
  • Forty-eight rats were divided into control, infection+saline, CEQ-PLGA-MS, and CEQ-INJ groups.
  • Animals received intravenous injections of 12.5 mg/kg of CEQ-PLGA-MS or CEQ-INJ.

Main Results:

  • CEQ-PLGA-MS treatment significantly reduced bacterial colonies in lung tissue compared to CEQ-INJ.
  • CEQ-PLGA-MS treatment led to lower levels of inflammatory cytokines (TNF-α, IL-1β, IL-6, IL-4) in bronchoalveolar lavage fluid.
  • Reduced inflammation severity scores were observed in the CEQ-PLGA-MS group at 48 hours post-treatment.

Conclusions:

  • CEQ-PLGA-MS exhibits superior therapeutic effects compared to CEQ-INJ for Klebsiella pneumoniae lung infections in rats.
  • CEQ-PLGA-MS represents a promising alternative for controlling lung infections caused by important pathogens.
Keywords:
Klebsiella pneumoniacefquinomeinflammationpharmacodynamicspoly lactic-co-glycolic acid microspheres

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