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Updated: Jan 27, 2026

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
Published on: July 20, 2022
Left atrial volume index and left ventricular global longitudinal strain predict new-onset atrial fibrillation in
Kenneth Bruun Pedersen1, Charlotte Madsen2, Niels Christian Foldager Sandgaard3
1Department of Cardiology, Odense University Hospital, Sdr. Boulevard 29, 5000, Odense C, Odense, Denmark. KennethBruunPedersen@gmail.com.
Insights
Echocardiography can predict atrial fibrillation (AF) in patients with transient ischemic attack (TIA). Larger left atrial volumes and depressed left ventricular function identified via echocardiography may indicate AF risk.
Area of Science:
- Cardiology
- Neurology
- Medical Imaging
Background:
- Atrial fibrillation (AF) is a common arrhythmia that increases stroke risk.
- Transient ischemic attack (TIA) is a warning sign for future stroke, often associated with AF.
- Non-invasive methods to predict AF in TIA patients are crucial for timely intervention.
Purpose of the Study:
- To investigate echocardiographic parameters for predicting AF in TIA patients.
- To assess the relationship between left atrial (LA) and left ventricular (LV) function and AF detection.
- To determine if echocardiography can guide AF monitoring strategies in TIA patients.
Main Methods:
- 110 TIA patients without prior stroke or AF underwent echocardiography.
- Patients were monitored using ECG, 72-hour Holter, and implantable cardiac monitors (ICM).
- Echocardiographic parameters including LA volume, LA emptying fraction, LV ejection fraction, and LV global longitudinal strain were analyzed.
Main Results:
- AF was detected in 14 patients (12.7%) during follow-up.
- Patients with AF showed significantly larger LA volumes (2D and 3D) and depressed LA function (LA emptying fraction).
- AF patients also exhibited depressed LV function, including lower LV ejection fraction and reduced LV global longitudinal strain.
Conclusions:
- Echocardiographic assessment of LA and LV size and function can noninvasively predict AF in TIA patients.
- These findings suggest echocardiography may help identify TIA patients at higher risk for AF.
- Echocardiographic data could potentially guide the intensity and duration of AF monitoring in TIA patients.
Abstract:
This study aimed to investigate different echocardiographic parameters for predicting atrial fibrillation (AF) in patients with transient ischemic attack (TIA). Echocardiography was performed in 110 patients (median age 65.8 years, 53% males) with TIA and no history of stroke or AF. All patients underwent monitoring with ECG and 72 h Holter-monitoring, and if no AF was found, an insertable cardiac monitor (ICM) was implanted and patients were followed for a median of 2.2 years. AF was found in 14 patients: five with Holter-monitoring and nine with ICM. AF patients had significantly larger left atrial (LA) volumes indexes compared to patients without AF (26.7 vs. 33.7 ml/m2, P = 0.03 for 2D images and 26.5 vs. 33.5 ml/m2, P = 0.0008 for 3D images). Patients with AF also had depressed LA function assessed with LA emptying fraction measured with 2D echocardiography (46.3 vs. 57.3%, P = 0.005 for patients with and without AF, respectively). Patients with AF also had depressed left ventricular (LV) function compared to patients without AF. LV ejection fraction was 55 versus 61%, P = 0.04 in patients with and without AF, respectively. LV global longitudinal strain (absolute value) was 16.7 in patients with AF compared to 21.2 in patients without AF (P = 0.001). Echocardiographic measurements of LA and LV size and function can noninvasively predict AF in patients with TIA and could potentially be used to guide AF monitoring strategy.
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