Related Experiment Video

Updated: Jan 27, 2026

In vivo Macrophage Imaging Using MR Targeted Contrast Agent for Longitudinal Evaluation of Septic Arthritis

In vivo Macrophage Imaging Using MR Targeted Contrast Agent for Longitudinal Evaluation of Septic Arthritis

Published on: October 20, 2013

Can pre-hospital administration reduce time to initial antibiotic therapy in septic patients?

Daniel Cudini^1,2, Karen Smith^2,3,4,5, Stephen Bernard^4,6

¹Clinical Operations, Ambulance Victoria, Melbourne, Victoria, Australia.

Emergency Medicine Australasia : EMA

|March 30, 2019

Abstract

Objective:

To quantify the potential time saved with pre-hospital antibiotic therapy in sepsis.

Methods:

Study data for adult patients transported by Ambulance Victoria (AV), and enrolled into the Australasian Resuscitation In Sepsis Evaluation (ARISE), were linked with pre-hospital electronic records.

Results:

An AV record was identified for 240 of 341 ARISE patients. The pre-hospital case notes referred to potential infection in 165 patients. The median time to first antibiotic administration from loading the patient into the ambulance was 107 (74-160) min.

Conclusions:

ARISE patients in Victoria were frequently identified pre-hospital. An opportunity exists to study the feasibility of pre-hospital antibiotic therapy.

Keywords:

antibiotics out of hospital pre-hospital sepsis sepsis management

More Related Videos

Characterizing Salmonella Typhimurium-induced Septic Peritonitis in Mice

Characterizing Salmonella Typhimurium-induced Septic Peritonitis in Mice

Published on: July 29, 2022

Transarterial Administration of Oncolytic Viruses for Locoregional Therapy of Orthotopic HCC in Rats

Transarterial Administration of Oncolytic Viruses for Locoregional Therapy of Orthotopic HCC in Rats

Published on: April 15, 2016

Related Concept Videos

Hospitals-II

Hospitals-II

Hospitals provide inpatient and outpatient services. Inpatient services provide care to patients that stay in the hospital for an extended period, ranging from days to months. Examples of inpatient services include intensive care units, hospital wards, or surgeries. Outpatient services provide care to patients who come to a hospital for a diagnostic or treatment but do not stay overnight —for example, diagnostic tests, surgical procedures, or health education.
Nurses that work in...

Handwashing II: Pre-procedure and Initial Procedure Steps

Handwashing II: Pre-procedure and Initial Procedure Steps

The pre-procedure steps of handwashing include removing jewelry and rolling up sleeves. However, many organizations allow staff to wear wedding rings.
The hand washing procedure itself includes the following steps. First, cover cuts, if any, on hands with a waterproof dressing. Cuts and abrasions can become contaminated with bacteria hindering the ability to clean the area thoroughly. In addition, repeated hand washing can worsen an injury. The nails must be short and clean, without nail...

Hospitals-I

Hospitals-I

Hospitals offer medical and surgical care to the sick and injured, along with accommodation while they recover. At the same time, they also provide outpatient, emergency, psychiatric, and rehabilitation services to meet various community needs. In addition to providing medical care, hospitals also act as hubs for medical research and training. Hospitals use clinical procedures and evidence-based practice standards to deliver patient care. To deliver safe and efficient care, a nurse must stay up...

Drug Administration and Therapy Phases: Overview

Drug Administration and Therapy Phases: Overview

Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...

Initiation of Translation

Initiation of Translation

Initiating translation is complex because it involves multiple molecules. Initiator tRNA, ribosomal subunits, and eukaryotic initiation factors (eIFs) are all required to assemble on the initiation codon of mRNA. This process consists of several steps that are mediated by different eIFs.
First, the initiator tRNA must be selected from the pool of elongator tRNAs by eukaryotic initiation factor 2 (eIF2). The initiator tRNA (Met-tRNAi) has conserved sequence elements including modified bases at...

Initiation of Translation

Initiation of Translation

Articles linked to this work by shared authors, journal, and citation graph.

Emergency Medical Service Identification and Prehospital Care of Acute Coronary Syndrome Among Culturally and Linguistically Diverse Immigrants: Statewide Linkage Study.

Journal of the American Heart Association·2026

Sex-Based Differences in Atrial Fibrillation: Epidemiology, Prehospital Care, Hospital Management, and Outcomes.

Journal of the American Heart Association·2026

Patient-reported outcomes and experience measures in clinical trials of critically ill adults with sepsis: a scoping review.

Annals of the American Thoracic Society·2026

Effect size and event rate estimation in neurocritical care randomised clinical trials: a protocol for a systematic review.

BMJ open·2025

A Pharmacokinetic Analysis of Intravenous Fluconazole in Adult Patients Undergoing Mechanical Circulatory Support Device Implantation.

Clinical pharmacokinetics·2025

Revising the Ambulance Clinical Response Model in Victoria, Australia: The Impact on Patient Safety.

Emergency medicine Australasia : EMA·2025

See all related articles