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Liposome-Encapsulated Curcumin-Loaded 3D Printed Scaffold for Bone Tissue Engineering
Naboneeta Sarkar1, Susmita Bose1
1W. M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering , Washington State University , Pullman , Washington 99164 , United States.
ACS Applied Materials & Interfaces
|March 30, 2019
Summary
This study enhances curcumin bioavailability using liposomes within 3D printed scaffolds. The novel scaffolds eliminate bone cancer cells while promoting healthy bone cell growth for tissue engineering.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Nanotechnology
Background:
- Curcumin, from turmeric, has therapeutic potential but poor bioavailability.
- Effective delivery systems are needed to harness curcumin's benefits.
- 3D printed scaffolds offer patient-specific solutions for bone regeneration.
Purpose of the Study:
- To enhance curcumin bioavailability via liposomal encapsulation.
- To incorporate liposomal curcumin into 3D printed calcium phosphate scaffolds.
- To evaluate the effect of liposomal curcumin on osteosarcoma and osteoblast cells.
Main Methods:
- Liposomal encapsulation of curcumin.
- Fabrication of 3D printed calcium phosphate scaffolds with designed porosity.
- In vitro testing of liposomal curcumin released from scaffolds on hFOB and MG-63 cells.
Main Results:
- Successful encapsulation of curcumin into liposomes.
- Liposomal curcumin from 3D printed scaffolds demonstrated significant cytotoxicity to osteosarcoma cells.
- Promoted viability and proliferation of healthy osteoblast cells.
Conclusions:
- Developed bifunctional 3D printed scaffolds with enhanced liposomal curcumin delivery.
- Scaffolds show potential for treating bone defects by targeting cancer cells and promoting bone healing.
- Combines additive manufacturing with natural compounds for advanced tissue engineering applications.
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