Related Experiment Video
Updated: Jan 27, 2026

Multifractal Spectrum Analysis for Assessing Pulmonary Nodule Malignancy
Published on: January 10, 2025
Extensive Skull Base Osteomyelitis Secondary to Malignant Otitis Externa
Luca Bruschini1, Stefano Berrettini1, Cambi Christina1
1ENT Audiology and Phoniatric Unit, University Hospital of Pisa, Pisa, Italy.
Abstract:
Skull base osteomyelitis is a severe complication of malignant otitis externa that affects the marrow of the temporal, sphenoid, and occipital bones. Skull base osteomyelitis is usually diagnosed based on clinical, microbiological, and radiological findings. Here, we present the imaging findings of a 76-year-old man who initially presented with right-sided malignant otitis externa, with the involvement of the otomastoid structures and ipsilateral temporal bone. Over the following 3 years, despite specific extended antibiotic therapy, the skull base osteomyelitis entirely involved the skull base, up to the contralateral petrous portion of the temporal bone, and it affected the cervical vertebral processes. This report describes an exceptional extent of unilateral malignant otitis externa with a severe involvement of the skull base on the contralateral side and the cervical spine.
Insights
Skull base osteomyelitis, a complication of malignant otitis externa, can spread extensively. This case shows severe skull base and cervical spine involvement, even contralaterally, over three years.
Area of Science:
- Radiology
- Infectious Diseases
- Otolaryngology
Background:
- Skull base osteomyelitis is a severe complication of malignant otitis externa.
- Diagnosis typically relies on clinical, microbiological, and radiological assessments.
Observation:
- A 76-year-old man presented with right-sided malignant otitis externa involving otomastoid structures and the temporal bone.
- Over three years, skull base osteomyelitis progressed despite antibiotic therapy.
Findings:
- The infection spread to involve the entire skull base, including the contralateral petrous temporal bone.
- Cervical vertebral processes were also affected, demonstrating an exceptional extent of disease.
Implications:
- This case highlights the potential for aggressive progression of malignant otitis externa and skull base osteomyelitis.
- It underscores the importance of comprehensive imaging and long-term monitoring for extensive infections.
Related Concept Videos
Sutures of the Skull
Sutures are immobile joints between adjacent bones of the skull. The narrow gap between the bones is filled with dense, fibrous connective tissue that unites the bones. The long sutures located between the skull bones are not straight but instead follow irregular, tightly twisting paths. These twisting lines tightly...
Overview of the Skull
The cranial vault surrounds and protects the brain and houses the middle and inner ear structures. This cavity is bounded superiorly by the rounded top of the skull, which...
Secondary Active Transport
Secondary Active Transport
Secondary Healthcare System
Primary and Secondary Growth in Roots and Shoots

