Related Experiment Video

Updated: Jan 27, 2026

A Retrospective Study on Endoscopic Surgery for the Treatment of Paravertebral Abscess in Spinal Tuberculosis Patients
03:47

A Retrospective Study on Endoscopic Surgery for the Treatment of Paravertebral Abscess in Spinal Tuberculosis Patients

Published on: October 25, 2024

636

Abdominal Surgery in Patients With Idiopathic Noncirrhotic Portal Hypertension: A Multicenter Retrospective Study

Laure Elkrief1,2, José Ferrusquia-Acosta3, Audrey Payancé4

  • 1Service de Transplantation, Hôpitaux Universitaires de Genève, Geneva, Switzerland.

Hepatology (Baltimore, Md.)
|March 30, 2019
PubMed

Insights

Patients with idiopathic noncirrhotic portal hypertension (INCPH) face high surgical risks, especially with extrahepatic conditions, ascites, or elevated creatinine. These factors increase the likelihood of severe complications and unfavorable outcomes following abdominal surgery.

Area of Science:

  • Gastroenterology
  • Hepatology
  • Surgical Oncology

Background:

  • Idiopathic noncirrhotic portal hypertension (INCPH) presents limited data regarding surgical morbidity and mortality.
  • Abdominal surgery in INCPH patients carries potential risks that require careful evaluation.

Purpose of the Study:

  • To retrospectively analyze the outcomes of abdominal surgery in patients diagnosed with INCPH.
  • To identify risk factors associated with surgical and portal hypertension-related complications in this patient cohort.

Main Methods:

  • Retrospective analysis of patient charts within the Vascular Liver Disease Interest Group network.
  • Inclusion of 44 patients with biopsy-proven INCPH undergoing abdominal surgery.
  • Assessment of complications (Dindo-Clavien grade ≥3), portal hypertension-related events, and mortality within specified timeframes.

Main Results:

  • Twenty percent of patients experienced major complications (Dindo-Clavien grade ≥3) within one month.
  • Thirty-three percent had portal hypertension-related complications within three months, associated with extrahepatic conditions and ascites history.
  • Six-month mortality was 9%, significantly higher in patients with serum creatinine ≥100 μmol/L (33% vs 0%).
  • Unfavorable outcomes were linked to extrahepatic conditions, ascites, and elevated creatinine levels.

Conclusions:

  • Patients with INCPH undergoing abdominal surgery are at significant risk for major complications.
  • The presence of extrahepatic conditions, a history of ascites, or elevated serum creatinine are key predictors of adverse outcomes.
  • Risk stratification is crucial for managing INCPH patients requiring surgical intervention.

More Related Videos

Invasive Hemodynamic Characterization of the Portal-hypertensive Syndrome in Cirrhotic Rats09:37

Invasive Hemodynamic Characterization of the Portal-hypertensive Syndrome in Cirrhotic Rats

Published on: August 1, 2018

15.5K
Contrast-Enhanced Subharmonic Aided Pressure Estimation SHAPE Using Ultrasound Imaging with a Focus on Identifying Portal Hypertension06:20

Contrast-Enhanced Subharmonic Aided Pressure Estimation SHAPE Using Ultrasound Imaging with a Focus on Identifying Portal Hypertension

Published on: December 5, 2020

2.9K

Related Concept Videos

Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
491
Hepatic Portal System01:21

Hepatic Portal System

The hepatic portal system, a critical part of our circulatory framework, transports nutrient-laden, deoxygenated blood from the gastrointestinal tract and spleen to the liver. This ingenious system plays an indispensable role in maintaining our body's metabolic equilibrium.
At its core, the hepatic portal vein is the result of a confluence of the superior and inferior mesenteric veins along with the splenic vein. Each of these veins has a unique role. The superior mesenteric vein is...
5.7K
Abdominal Aorta01:25

Abdominal Aorta

Once the aorta traverses the diaphragmatic plane at the aortic hiatus, it is known as the abdominal aorta. This anatomical structure is positioned leftward of the spinal column, encased within a cocoon of adipose tissue behind the peritoneal cavity. It terminates at the L4 vertebra, where it splits into the common iliac arteries. Prior to this bifurcation, the abdominal aorta gives rise to several vital branches.
The celiac trunk, a singular artery, divides into the left gastric artery, which...
2.2K
Hypertension V: Nursing Management01:23

Hypertension V: Nursing Management

The nursing management of hypertension involves accurately assessing symptoms, making a comprehensive nursing diagnosis, collaborating with patients to set goals, and implementing targeted interventions to mitigate the condition's impact and improve patient well-being.Comprehensive AssessmentThe initial step in nursing care for hypertension involves a thorough patient assessment. It includes evaluating symptoms such as headaches, dizziness, blurred vision, and previous hypertension episodes.
398
Hypertension I: Introduction01:28

Hypertension I: Introduction

Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
803
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
892