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Fatigue, Physical and Functional Mobility, and Obesity in Pediatric Cancer Survivors

Masoumeh Karimi1, Amanda D Cox, Sabrina V White

  • 1Authors Affiliation: Division of Hematology/Oncology, Department of Pediatrics (Dr Karimi, Ms Cox, and Dr Karlson), Department of Psychiatry (Dr Karlson), and Division of Child Development, Pediatric Research Division (Ms Cox), and Center for Advancement of Youth (Ms White), Department of Pediatrics, University of Mississippi Medical Center, Jackson.

Cancer Nursing
|March 30, 2019
PubMed

Insights

Childhood cancer survivors experiencing fatigue may benefit from interventions addressing depression and mobility. Recent survivors

Area of Science:

  • Pediatric Oncology
  • Psychosocial Oncology
  • Cancer Survivorship Research

Background:

  • Childhood cancer survivors face increased risks of chronic health issues, including cardiovascular disease, fatigue, weight problems, and emotional disturbances.
  • The long-term effects of cancer treatment necessitate ongoing monitoring and management of late effects in survivors.

Purpose of the Study:

  • To investigate the relationship between depression, mobility, fatigue, and body mass index in childhood cancer survivors using the biopsychosocial model.
  • To identify key predictors of fatigue and elevated body mass index in this vulnerable population.

Main Methods:

  • A cohort of 144 childhood cancer survivors was analyzed.
  • Data collection included patient-reported outcomes (PROMIS 1.0), family symptom inventories, and objective measurements of height and weight.
  • Hierarchical linear regression was employed to analyze the associations between variables.

Main Results:

  • Greater depression and lower mobility significantly predicted increased fatigue in survivors (adjusted R² = 0.54).
  • Shorter time since diagnosis was also associated with higher fatigue levels.
  • Older age and not receiving chemotherapy predicted higher body mass index (adjusted R² = 0.051).

Conclusions:

  • Fatigue in childhood cancer survivors tends to improve post-treatment but is associated with depression and reduced mobility in recent survivors.
  • Interventions targeting depression and improving mobility may be clinically beneficial for survivors experiencing fatigue.
  • Weight status in recent survivors is complex, influenced by biological and treatment factors, with psychological and social impacts requiring further study.
Abstract

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