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HIV and cART-Associated Dyslipidemia Among HIV-Infected Children

Birkneh Tilahun Tadesse1,2, Byron Alexander Foster3, Adugna Chala4

  • 1Department of Pediatrics, College of Medicine and Health Sciences, Hawassa University, Hawassa 1560, Ethiopia. birknehtilahun@gmail.com.

Journal of Clinical Medicine
|March 31, 2019
PubMed

Insights

HIV-infected children on combination antiretroviral therapy (cART) show higher dyslipidemia rates, especially low HDLc and hypertriglyceridemia. Regular lipid monitoring is crucial for these children.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Cardiovascular Health

Background:

  • Persistent dyslipidemia in children increases cardiovascular risks and impacts combination antiretroviral therapy (cART) outcomes.
  • HIV-infected children are particularly vulnerable to dyslipidemia, influenced by both the virus and its treatment.

Purpose of the Study:

  • To evaluate the prevalence and predictors of dyslipidemia in HIV-infected Ethiopian children.
  • To compare dyslipidemia rates between children treatment-naïve and those on cART.

Main Methods:

  • Enrolled 105 cART-naïve and 215 cART-experienced HIV-infected children from nine centers.
  • Collected demographic, clinical, and lipid profile data, including cART type, adherence, and duration.
  • Defined dyslipidemia using established cholesterol and triglyceride thresholds.

Main Results:

  • Dyslipidemia prevalence was higher in cART-experienced (70.2%) versus treatment-naïve (58.1%) children.
  • Low HDLc (40.2% vs. 23.4%) and hypertriglyceridemia (47.2% vs. 35.8%) were significantly more common in cART-experienced children.
  • Nutrition status was linked to dyslipidemia in cART-naïve children.

Conclusions:

  • A high prevalence of cART-associated dyslipidemia, particularly low HDLc and hypertriglyceridemia, exists in treatment-experienced HIV-infected children.
  • These findings highlight the necessity of routine lipid monitoring for children undergoing cART.
Abstract

Keywords:
HIVcARTchildrendyslipidemias

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