Related Experiment Video

Updated: Jan 27, 2026

Using RNA-sequencing to Detect Novel Splice Variants Related to Drug Resistance in In Vitro Cancer Models
09:58

Using RNA-sequencing to Detect Novel Splice Variants Related to Drug Resistance in In Vitro Cancer Models

Published on: December 9, 2016

14.3K

Molecular insights into cancer drug resistance from a proteomics perspective

Yao An1,2, Li Zhou1, Zhao Huang1

  • 1a West China School of Basic Medical Sciences & Forensic Medicine , Sichuan University , Chengdu , PR China.

Expert Review of Proteomics
|March 31, 2019
PubMed
Abstract

Insights

Proteomics research is uncovering biomarkers for cancer drug resistance. Understanding protein changes and modifications is crucial for developing targeted therapies for drug-resistant cancers.

Area of Science:

  • Oncology
  • Proteomics
  • Biomarker Discovery

Background:

  • Cancer treatment faces significant challenges from drug resistance and the need for targeted therapies.
  • Comparative proteomics has identified potential biomarkers for cancer drug resistance, aiding drug target discovery and personalized medicine.

Purpose of the Study:

  • To review recent advances and challenges in proteomics for cancer drug resistance research.
  • To emphasize biomarker discovery and understanding protein interactions in signaling pathways.
  • To highlight the role of post-translational modifications (PTMs) in drug resistance mechanisms.

Main Methods:

  • Review of current literature on proteomics studies in cancer drug resistance.
  • Analysis of mass spectrometry (MS)-based proteomics technologies.
  • Focus on biomarker identification and PTMs in drug-resistant cancer.

Main Results:

  • Proteomics studies have identified candidate proteins as biomarkers for drug resistance.
  • Post-translational modifications (PTMs) play a critical role in the mechanisms of cancer drug resistance.
  • Advances in MS-based proteomics enable in-depth investigation of resistance mechanisms.

Conclusions:

  • Deciphering proteome profiles and PTMs is key to understanding cancer treatment resistance.
  • Proteomics facilitates the discovery of biomarkers and molecular mechanisms for individualized cancer therapies.
  • This research supports the development of personalized therapeutic strategies for drug-resistant cancer patients.
Keywords:
Cancer drug resistanceCyTOFPTMsbiomarker discoverycomparative proteomicsmass spectrometrypersonalized medicine

More Related Videos

Preparation of Mitochondria from Ovarian Cancer Tissues and Control Ovarian Tissues for Quantitative Proteomics Analysis11:51

Preparation of Mitochondria from Ovarian Cancer Tissues and Control Ovarian Tissues for Quantitative Proteomics Analysis

Published on: November 18, 2019

6.3K
Generation of Prostate Cancer Cell Models of Resistance to the Anti-mitotic Agent Docetaxel06:44

Generation of Prostate Cancer Cell Models of Resistance to the Anti-mitotic Agent Docetaxel

Published on: September 8, 2017

14.0K

Related Concept Videos

Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.7K
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
1.8K
Psychodynamic Perspectives on Personality01:27

Psychodynamic Perspectives on Personality

The psychodynamic perspective in psychology asserts that most personality functions operate unconsciously, outside of awareness. This means that the motives and emotions driving behavior often remain hidden, automatically buried in the unconscious mind as a defense mechanism to shield us from psychological distress. According to this theory, the unconscious mind contains thoughts, memories, and emotions that are too disturbing to face directly.
Psychodynamic theorists argue that unconscious...
1.6K
Molecular Models02:00

Molecular Models

Physical models representing molecular architectures of chemical compounds play essential roles in understanding chemistry. The use of molecular models makes it easier to visualize the structures and shapes of atoms and molecules.
43.6K
The Behavioral Perspective on Personality01:19

The Behavioral Perspective on Personality

Behaviorists view personality as primarily shaped by environmental reinforcements and consequences. According to this perspective, behavior is influenced by external stimuli, and individuals adjust their actions based on rewards and punishments. Over time, learning histories — accumulated patterns of reinforcement — play a significant role in shaping personality. Behaviors that lead to positive outcomes are reinforced, while those resulting in negative outcomes are diminished.
823
Criticisms of the Evolutionary Perspective01:23

Criticisms of the Evolutionary Perspective

In a study where individuals posing as strangers offered compliments and proposed casual sex to students, the responses differed significantly based on gender. Not a single woman accepted the proposal, while 70% of the men agreed. This outcome provides a useful scenario to explore through the lens of evolutionary psychology and social learning theory, highlighting the diverse perspectives on human sexual behaviors.
Evolutionary psychology provides one explanation for these findings, suggesting...
348