Related Experiment Video

Updated: Jan 27, 2026

Cell Death Associated with Abnormal Mitosis Observed by Confocal Imaging in Live Cancer Cells
15:53

Cell Death Associated with Abnormal Mitosis Observed by Confocal Imaging in Live Cancer Cells

Published on: August 21, 2013

15.5K

Ferroptosis, a new form of cell death: opportunities and challenges in cancer

Yanhua Mou1,2, Jun Wang2, Jinchun Wu1

  • 1Department of Oncology, Xiangya Hospital, Central South University, Changsha, 410008, People's Republic of China.

Journal of Hematology & Oncology
|March 31, 2019
PubMed

Insights

Ferroptosis, a distinct cell death, shows promise in cancer therapy. This review explores its regulation, role of ncRNAs, and potential as a therapeutic strategy for various cancers.

Area of Science:

  • Oncology
  • Cell Death Biology

Background:

  • Ferroptosis is a regulated cell death pathway with unique biochemical characteristics.
  • Dysregulation of ferroptosis is implicated in the pathogenesis of various diseases, particularly cancers.
  • Emerging research highlights ferroptosis's potential as a therapeutic target in oncology.

Purpose of the Study:

  • To review current findings on ferroptosis regulation in cancer.
  • To elucidate the role of non-coding RNAs (ncRNAs) in ferroptosis.
  • To discuss the relationship between ferroptosis and other regulated cell death mechanisms.

Main Methods:

  • Literature review of ferroptosis research, focusing on ncRNA involvement.
  • Analysis of aberrant ferroptosis in different cancer types.
  • Examination of novel ferroptosis inducers, including conventional drugs and natural compounds.

Main Results:

  • ncRNAs play a significant role in mediating ferroptosis.
  • Ferroptosis is aberrantly regulated across diverse cancer types.
  • Conventional drugs and natural compounds can act as ferroptosis inducers.

Conclusions:

  • Ferroptosis induction presents a promising therapeutic strategy for cancer treatment.
  • Further research into ferroptosis regulation and its clinical applications is warranted.
  • Understanding ferroptosis's interplay with other cell death pathways may enhance therapeutic efficacy.
Keywords:
ApoptosisAutophagyCancersFerroptosisNcRNAsP53

More Related Videos

Assessing Cell Viability and Death in 3D Spheroid Cultures of Cancer Cells10:33

Assessing Cell Viability and Death in 3D Spheroid Cultures of Cancer Cells

Published on: June 16, 2019

29.3K
Evaluating Cell Death Using Cell-Free Supernatant of Probiotics in Three-Dimensional Spheroid Cultures of Colorectal Cancer Cells06:07

Evaluating Cell Death Using Cell-Free Supernatant of Probiotics in Three-Dimensional Spheroid Cultures of Colorectal Cancer Cells

Published on: June 13, 2020

7.1K

Related Concept Videos

Overview of Cell Death01:30

Overview of Cell Death

Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance between the two may lead to cancer or autoimmune diseases.
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the...
9.6K
Autophagic Cell Death01:18

Autophagic Cell Death

Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and...
4.4K
Production of Formed Elements01:34

Production of Formed Elements

Hemangioblasts are multipotent stem cells originating from the mesoderm. They give rise to hematopoietic stem cells (HSCs), which undergo hematopoiesis to produce all the formed elements of blood. This process is regulated by a complex network of hematopoietic growth factors, including transcription factors, growth factors, and cytokines. These factors stimulate the HSCs to divide and differentiate, though some HSCs remain undifferentiated to maintain a self-renewing pool.
Most HSCs commit to...
3.9K
Discharge Summary Forms01:31

Discharge Summary Forms

The discharge summary is crucial as it enables a smooth transition from a healthcare facility to a patient's home or another care setting. This critical document facilitates seamless continuity of care, ensuring patients receive the necessary support and attention.
Here's a detailed look at the key components and guidelines for preparing a discharge summary:
1.3K
Cartesian Form for Vector Formulation01:26

Cartesian Form for Vector Formulation

The Cartesian form for vector formulation is a process to calculate  the moment of force using the position and force vectors. The moment of force is defined as the cross-product of these vectors, making it a vector quantity. The Cartesian form of the position and force vectors involves unit vectors, which can be used to express the cross-product in determinant form.
1.1K
Cancer Cell Migration through Invadopodia01:35

Cancer Cell Migration through Invadopodia

Invadosome is a broad category of cell surface structures with proteolytic activity that  degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However,...
3.2K