Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Biological Clocks and Seasonal Responses02:45

Biological Clocks and Seasonal Responses

41.6K
The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
41.6K
Simplified Synchronous Machine Model01:30

Simplified Synchronous Machine Model

760
The Synchronous Machine Model is a fundamental tool in analyzing and ensuring the transient stability of power systems. This model simplifies the representation of a synchronous machine under balanced three-phase positive-sequence conditions, assuming constant excitation and ignoring losses and saturation. The model is pivotal for understanding the behavior of synchronous generators connected to a power grid, particularly during transient events.
In this model, each generator is connected to a...
760
Dynamic Equilibrium02:20

Dynamic Equilibrium

62.1K
A reversible chemical reaction represents a chemical process that proceeds in both forward (left to right) and reverse (right to left) directions. When the rates of the forward and reverse reactions are equal, the concentrations of the reactant and product species remain constant over time and the system is at equilibrium. A special double arrow is used to emphasize the reversible nature of the reaction. The relative concentrations of reactants and products in equilibrium systems vary greatly;...
62.1K
Production of Formed Elements01:34

Production of Formed Elements

3.9K
Hemangioblasts are multipotent stem cells originating from the mesoderm. They give rise to hematopoietic stem cells (HSCs), which undergo hematopoiesis to produce all the formed elements of blood. This process is regulated by a complex network of hematopoietic growth factors, including transcription factors, growth factors, and cytokines. These factors stimulate the HSCs to divide and differentiate, though some HSCs remain undifferentiated to maintain a self-renewing pool.
Most HSCs commit to...
3.9K
Discharge Summary Forms01:31

Discharge Summary Forms

1.3K
The discharge summary is crucial as it enables a smooth transition from a healthcare facility to a patient's home or another care setting. This critical document facilitates seamless continuity of care, ensuring patients receive the necessary support and attention.
Here's a detailed look at the key components and guidelines for preparing a discharge summary:
1.3K
Three-Phase Short Circuit—Unloaded Synchronous Machine01:21

Three-Phase Short Circuit—Unloaded Synchronous Machine

684
Conducting a three-phase short circuit test on an unloaded synchronous machine helps understand its impact on the system. The AC fault current's oscillogram, with the DC offset removed, reveals that the waveform amplitude decreases from an initially high value to a steady-state level for one phase of the machine.
This behavior occurs due to the magnetic flux produced by the short-circuit armature currents. Initially, these currents follow high-reluctance paths but eventually shift to...
684

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

STIPS algorithm enables tracking labyrinthine patterns and reveals distinct rhythmic dynamics of actin microridges.

Physical biology·2025
Same author

A deep learning framework for quantitative analysis of actin microridges.

NPJ systems biology and applications·2023
Same author

Spatial correlations in a finite-range Kuramoto model.

Physical review. E·2020
Same author

Microridges are apical epithelial projections formed of F-actin networks that organize the glycan layer.

Scientific reports·2019
Same author

A framework for quantification and physical modeling of cell mixing applied to oscillator synchronization in vertebrate somitogenesis.

Biology open·2017
Same author

Correction: Object Segmentation and Ground Truth in 3D Embryonic Imaging.

PloS one·2016

Related Experiment Video

Updated: Jan 27, 2026

Generation of Dispersed Presomitic Mesoderm Cell Cultures for Imaging of the Zebrafish Segmentation Clock in Single Cells
10:41

Generation of Dispersed Presomitic Mesoderm Cell Cultures for Imaging of the Zebrafish Segmentation Clock in Single Cells

Published on: July 24, 2014

14.3K

Segmentation clock dynamics is strongly synchronized in the forming somite.

Rajasekaran Bhavna1

  • 1Max Planck Institute of Molecular Cell Biology and Genetics, 01307, Dresden, Germany; Max Planck Institute for the Physics of Complex Systems, 01187, Dresden, Germany; Tata Institute of Fundamental Research, 400005, Mumbai, India.

Developmental Biology
|March 31, 2019
PubMed
Summary

Vertebrate segmentation relies on a clock mechanism. This study reveals how cell movements and synchronized oscillations of the Her1 protein in the presomitic mesoderm (PSM) create precise somite boundaries during development.

Keywords:
Cell mixingCoupled periodsFrequency profilePhase order parameterSegmentation clock dynamicsSingle cell oscillator phasesSynchronization strength

More Related Videos

Author Spotlight: Investigating Islet Abnormalities and Function with a Pseudoislet Protocol
08:04

Author Spotlight: Investigating Islet Abnormalities and Function with a Pseudoislet Protocol

Published on: November 3, 2023

2.4K
Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters
10:38

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters

Published on: September 27, 2012

23.1K

Related Experiment Videos

Last Updated: Jan 27, 2026

Generation of Dispersed Presomitic Mesoderm Cell Cultures for Imaging of the Zebrafish Segmentation Clock in Single Cells
10:41

Generation of Dispersed Presomitic Mesoderm Cell Cultures for Imaging of the Zebrafish Segmentation Clock in Single Cells

Published on: July 24, 2014

14.3K
Author Spotlight: Investigating Islet Abnormalities and Function with a Pseudoislet Protocol
08:04

Author Spotlight: Investigating Islet Abnormalities and Function with a Pseudoislet Protocol

Published on: November 3, 2023

2.4K
Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters
10:38

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters

Published on: September 27, 2012

23.1K

Area of Science:

  • Developmental Biology
  • Systems Biology
  • Genetics

Background:

  • Vertebrate somitogenesis involves a segmentation clock coordinating spatiotemporal signaling for body axis patterning.
  • Understanding the interplay between cellular oscillations and tissue-level organization is crucial for developmental processes.

Purpose of the Study:

  • To simultaneously investigate cell movements and Her1 gene oscillations at single-cell resolution within the presomitic mesoderm (PSM).
  • To establish quantitative relationships between cellular oscillator dynamics and the overall somitogenesis period.
  • To explore the role of oscillator synchronization in forming precise somite boundaries.

Main Methods:

  • Simultaneous single-cell resolution tracking of cell movements and Her1 expression oscillations.
  • Quantitative analysis of oscillator phases and frequencies along the anterior-posterior PSM axis.
  • Mathematical modeling to relate cell-level oscillator periods to tissue-level somitogenesis periods.
  • Assessment of oscillator synchronization using phase order parameters.

Main Results:

  • A frequency profile gradient of cellular oscillators was identified along the anterior-posterior PSM axis.
  • Precise mathematical relationships were inferred between spatial cell-level periods and tissue-level somitogenesis periods.
  • Gradients in relative velocities of cellular oscillators were confirmed.
  • Partial synchronization was observed in the tailbud and posterior PSM, with near-complete synchronization in the presumptive somite region.

Conclusions:

  • Oscillator synchronization, potentially regulated by cell movement and the temporal phase of Her1, acts as a control mechanism for precise somite boundary formation.
  • The study provides a quantitative framework for understanding how cellular dynamics translate to tissue-level patterning during somitogenesis.