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Updated: Jan 27, 2026

Fabrication of Amyloid-β-Secreting Alginate Microbeads for Use in Modelling Alzheimer's Disease
Published on: July 6, 2019
Facile fabrication of core-shell/bead-like ethylenediamine-functionalized Al-pillared montmorillonite/calcium
Yongcun Song1, Songyan Wang1, Li-Ye Yang1
1School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316022, PR China.
Abstract:
In this study, a MT(Al)/calcium alginate [MT(Al)@CA] microsphere structure was prepared using sodium alginate (SA) and MT(Al). In order to achieve [MT(Al)@CA] microspheres with a high stability and chemical resistance, glutaraldehyde was used as the crosslinking agent to graft the microspheres and ethylenediamine (ED) into a new type of ED-functionalized MT(Al)@CA microsphere structure similar to a core-shell-type structure [MT(Al)@CA-ED]. This core-shell/bead-like structure was characterized and analyzed by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS). The adsorption performance of the core-shell/bead-like structure for As(V) in solution was studied. The effects of the initial As(V) concentration, reaction time, pH, and different reaction temperatures on the reaction process were studied. The results indicate that at a pH of 4, the removal rate of As(V) by the core-shell/bead-like MT(Al)@CA-ED could reach 94.85% after 150 min. The adsorption process is highly consistent with the Langmuir isotherm model (R2 = 0.9983) and pseudo-second-order kinetic model (R2 = 0.9973). The maximum adsorption capacity could reach 61.94 mg/g. Regeneration experiments showed that the adsorption efficiency of As(V) after six cycles was >80%.
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