Related Experiment Videos
Determinants of response to eucapneic hyperventilation with cold air in a population-based study
The American Review of Respiratory Disease
|September 1, 1986
Summary
Asthma and recent respiratory illness predict bronchial responsiveness to cold air challenges in young people. A lower FEF/FVC ratio further indicates responsiveness, particularly after illness restricting activity.
Area of Science:
- Pediatric Pulmonology
- Respiratory Medicine
- Epidemiology
Background:
- Bronchial responsiveness is a key indicator of airway function.
- Understanding factors influencing bronchial responsiveness is crucial for pediatric respiratory health.
Purpose of the Study:
- To identify factors associated with bronchial responsiveness to eucapneic hyperventilation with cold air in children, adolescents, and young adults.
- To investigate the predictive value of respiratory symptoms and lung function on cold air challenge response.
Main Methods:
- Population-based epidemiologic study.
- Analysis of eucapneic hyperventilation with cold air response as a continuous variable.
- Assessment of respiratory illness history and prechallenge forced expiratory flow (FEF) and forced vital capacity (FVC) ratios.
Main Results:
- Asthma or persistent wheeze in the prior year was significantly associated with cold air challenge response.
- A history of respiratory illness leading to activity restriction also predicted increased responsiveness.
- A low prechallenge FEF/FVC ratio was a significant predictor of responsiveness, especially in those with a history of activity-restricting respiratory illness.
Conclusions:
- Previous asthma, persistent wheeze, and recent activity-restricting respiratory illness are linked to heightened bronchial responsiveness in young individuals.
- Prechallenge FEF/FVC ratio is a valuable indicator of bronchial responsiveness, particularly in the context of recent respiratory illness.