Related Experiment Video
Updated: Jan 27, 2026

Isolation Method for Long-Term and Short-Term Hematopoietic Stem Cells
Published on: May 19, 2023
Short- and long-term results with a percutaneous treatment in critical hand ischaemia
Zoltán Ruzsa1,2, Balázs Berta1, Júlia Tóth2
1Heart and Vascular Center, Semmelweis University, Budapest, Hungary.
Insights
Percutaneous transluminal angioplasty is a feasible and safe treatment for critical hand ischemia (CHI), demonstrating high technical success and hand healing rates. Major adverse events (MAEs) are common due to patient comorbidities.
Area of Science:
- Vascular Surgery
- Interventional Cardiology
- Peripheral Artery Disease
Background:
- Critical hand ischemia (CHI) poses significant challenges for limb salvage.
- Percutaneous transluminal angioplasty and thrombolysis offer potential treatment options.
Purpose of the Study:
- To assess the feasibility, safety, and outcomes of endovascular treatment for CHI.
- To evaluate technical success, clinical success, and complication rates.
Main Methods:
- Prospective registry of 101 patients with CHI treated between 2012-2016.
- Angioplasty performed across three upper arm segments (subclavian, brachial, forearm).
- Assessment of technical/clinical success, major adverse events (MAEs), and complications at 1 year and long-term follow-up.
Main Results:
- High technical success (96.0%) and 1-year clinical success (84.2%) rates.
- Angioplasty targeted forearm vessels in 43.5% of cases; stenting in 46.8%.
- 1-year MAE rate was 26.9%, with low vascular access site complications (2.1%).
Conclusions:
- Endovascular angioplasty is a feasible and safe approach for treating CHI.
- Acceptable rates of technical success and hand healing were observed.
- High rates of MAEs are attributed to the prevalence of severe comorbidities in CHI patients.
Background:
The aim of this prospective registry was to determine the feasibility, safety, and outcomes of percutaneous transluminal angioplasty and thrombolysis in the treatment of critical hand ischemia (CHI).
Methods:
One-hundred one patients (aged 60.6 ± 15.3 years) were treated for CHI between 2012 and 2016 in three cardiovascular centers. Anatomically, the upper arm was divided into three segments (I-subclavian, II-brachial, and III-forearm). We examined the rates of technical and clinical success, major adverse events (MAEs), and vascular complications at 1 year and at long-term follow-up.
Results:
Nineteen patients (18.8%) were treated for acute CHI, and 82 (81.2%) for chronic CHI. Median follow-up was 36.9 (19.6-68.3) months. Clinical symptoms were isolated rest pain in 91 patients (90.1%) and digital ulcer or gangrene in 10 patients (9.9%). The technical and clinical success rate of intervention was 96.0% (97/101) and 84.2% (85/101) at 1 year. Angioplasty was performed in Segments I, II, and III in 28 (27.7%), in 29 (28.7%), and 44 (43.5%) patients. Stent implantation was necessary in 47 patients (46.8%). Vascular access site complications were found in 2.1% of the sample. After 1 year, MAEs occurred in 27 patients (26.9%), and the target lesion revascularization rate was 11.9%. In two patients (1.9%), thoracic sympatectomy was necessary, and two patients (1.9%) underwent minor finger amputations.
Conclusions:
Angioplasty of hand vessels for CHI is a feasible and safe procedure with acceptable rates of technical success and hand healing. MAEs are frequent because the rate of severe comorbidities is high.
Related Concept Videos
Critical Region, Critical Values and Significance Level
In hypothesis testing, a sample statistic is converted to a test statistic using z, t, or chi-square distribution. A critical region is an area under the curve in probability distributions demarcated by the critical value. When the test statistic falls in this region, it suggests that the null hypothesis must be rejected. As this region contains all those values of the...
Critical Values
Hand hygiene
Hand washing...
Critical Thinking
Colleges and universities are...
Critical Thinking I
Critical Thinking II

