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Neurofilament light chain as an indicator of exacerbation prior to clinical symptoms in multiple sclerosis
Keith R Edwards1, Lore Garten1, Judy Button1
1Multiple Sclerosis Center of Northeastern New York, 1182 Troy-Schenectady Road, Suite 203, Latham, NY 12110, United States.
Background:
Biomarkers may be a sensitive measure of disease activity in patients with multiple sclerosis (pwMS).
Objective:
A pwMS had a marked increase of neurofilament light chain (NfL) in CSF 9-weeks prior to a clinical exacerbation.
Methods And Results:
Brain MRI, CSF, EDSS were measured at baseline, 6 weeks and 28 weeks. The patient had an exacerbation at week 15 of study but the NfL measured at week 6 were found to show a nearly 3-fold increase of CSF NfL levels prior to symptoms when the NfL levels were later measured.
Conclusion:
This is an example supporting the usefulness of NfL in monitoring disease activity in pwMS which may predict disease activity prior to a clinical exacerbation.
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