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Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis
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Influence of Age Ranges on Relationship of Complex Aortic Plaque With Cervicocephalic Atherosclerosis in Ischemic

Qi Kong1, Xin Ma1, Chen Wang2

  • 1Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
|April 1, 2019
PubMed

Insights

Age significantly impacts the association between aortic plaque and cerebrovascular disease risk. Older patients show higher complex aortic plaque prevalence, but significant cervicocephalic stenosis only predicts it in middle-aged individuals.

Area of Science:

  • Cardiovascular research
  • Neurology
  • Medical imaging

Background:

  • Complex aortic plaque is a key cause of acute ischemic cerebrovascular disease.
  • It serves as a marker for systemic atherosclerosis.
  • Significant cervicocephalic atherosclerotic stenosis (≥50%) may indicate complex aortic plaque.

Purpose of the Study:

  • To investigate the influence of age ranges on the association between complex aortic plaque and acute ischemic cerebrovascular disease.
  • To refine risk estimation for complex aortic plaque based on age-specific factors.

Main Methods:

  • Computed tomography angiography was used to assess aortic arch and cervicocephalic arteries.
  • Patients were categorized into middle-aged (45-64 years) and old-aged (65-85 years) groups.
  • Complex aortic plaque was defined by ≥4 mm thickness, ulcerations, or mural thrombus.

Main Results:

  • Old-aged patients exhibited a higher prevalence of complex aortic plaque (67.3%) compared to middle-aged patients (30.9%).
  • In middle-aged patients, extracranial atherosclerotic stenosis independently predicted complex aortic plaque.
  • No correlation between complex aortic plaque and cervicocephalic stenosis was found in old-aged patients.

Conclusions:

  • Age is a critical factor in predicting complex aortic plaque in acute ischemic cerebrovascular disease.
  • The predictive value of cervicocephalic atherosclerotic stenosis for complex aortic plaque differs significantly between age groups.
Abstract

Keywords:
Complex aortic plaqueacute ischemic cerebrovascular diseaseage rangesrelationshipsignificant cervicocephalic atherosclerotic stenosis

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