Related Experiment Video
Updated: Jan 27, 2026
06:56
Human Fetal Blood Flow Quantification with Magnetic Resonance Imaging and Motion Compensation
Published on: January 7, 2021
2.8K
Quantification of Blood Flow in Dialysis Access Using Custom-Acquisition Protocol and Imaging Methods: A Clinical
Nischal Koirala1, Nikunj Chauhan2, Dustin Thompson2
1Department of Chemical and Biomedical Engineering, Cleveland State University, Cleveland, OH; Department of Biomedical Engineering, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195.
Journal of Vascular and Interventional Radiology : JVIR
|April 1, 2019
Summary
Digital subtraction angiography (DSA) at 6 frames/second provides the most accurate assessment of dialysis access blood flow, outperforming fluoroscopy and lower frame rates.
Area of Science:
- Medical Imaging
- Vascular Access
- Hemodynamics
Background:
- Accurate assessment of access blood flow (ABF) is crucial for managing hemodialysis vascular access.
- Malfunctioning accesses can lead to significant patient morbidity.
Purpose of the Study:
- To evaluate the accuracy of ABF rate quantification using 2D digital subtraction angiography (DSA) and fluoroscopy image sequences.
- To compare imaging-derived flow rates with catheter-based thermal dilution (TD) measurements.
Main Methods:
- 23 patients with suspected access malfunction underwent imaging with DSA (3 or 6 frames/second) and fluoroscopy (10 or 15 pulses/second).
- Access blood flow was quantified using a bolus tracking method with cross-correlation algorithm.
- Indicator-dilution curves were analyzed with gamma-variate (GV) fitting; radiation doses were assessed.
Main Results:
- DSA at 6 frames/second with GV fitting showed the lowest deviation (20% ± 4.1%) compared to TD measurements.
- Fluoroscopy at 15 pulses/second with GV fitting had a deviation of 48% ± 7.1%.
- DSA at 6 frames/second resulted in a mean peak skin dose of 3.28 mGy and effective dose of 75 μSv.
Conclusions:
- Digital subtraction angiography (DSA) imaging at 6 frames/second is the most accurate method for quantifying dialysis access blood flow.
- Image acquisition frame rate significantly impacts the accuracy of flow quantification.
Related Concept Videos
01:29Blood Flow
75.7K
Blood is pumped by the heart into the aorta, the largest artery in the body, and then into increasingly smaller arteries, arterioles, and capillaries. The velocity of blood flow decreases with increased cross-sectional blood vessel area. As blood returns to the heart through venules and veins, its velocity increases. The movement of blood is encouraged by smooth muscle in the vessel walls, the movement of skeletal muscle surrounding the vessels, and one-way valves that prevent backflow.
75.7K
01:27Dialysis
1.3K
Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
1.3K
01:15Dialysis
1.7K
Dialysis is a diffusion-based purification process that separates analyte molecules from a complex matrix. This is accomplished by allowing molecules in the solution to pass through a semipermeable membrane into a liquid on the other side. The membrane is usually made of cellulose acetate or cellulose nitrate, and the second liquid must be miscible with the solution. Ions (e.g., chloride or sodium) or organic molecules (e.g., glucose) can pass through the membrane pores, which generally have...
1.7K
01:17Autoregulation of Blood Flow
7.6K
Autoregulation mechanisms are characterized by their inherent capacity for self-regulation without necessitating specific nervous stimulation or endocrine control. These mechanisms facilitate the adjustment of blood flow and, therefore, perfusion specific to each tissue region. This self-regulation encompasses chemical signals and myogenic controls.
Chemical Signaling in Autoregulation
Chemical signaling operates at the precapillary sphincter level, inciting either contraction or relaxation....
Chemical Signaling in Autoregulation
Chemical signaling operates at the precapillary sphincter level, inciting either contraction or relaxation....
7.6K
01:25Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications
671
Peritoneal dialysis (PD) is a medical process that removes waste products and excess fluid from the body using the peritoneal membrane as a natural filter.Peritoneal Dialysis MethodsSeveral methods can be used for peritoneal dialysis, including Acute Intermittent Peritoneal Dialysis, Continuous Ambulatory Peritoneal Dialysis, and Automated Peritoneal Dialysis, also known as Continuous Cyclic Peritoneal Dialysis.Acute Intermittent Peritoneal Dialysis (AIPD) is used for patients with uremic...
671
01:29Reliability and Validity
13.8K
Reliability and validity are two important considerations that must be made with any type of data collection. Reliability refers to the ability to consistently produce a given result. In the context of psychological research, this would mean that any instruments or tools used to collect data do so in consistent, reproducible ways.
13.8K