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Ontogeny of cytokine responses to PHA from birth to adulthood

Mohamed Jeljeli1,2, Valérie Guérin-El Khourouj1,2, Béatrice Pédron1,2

  • 1Laboratory of Immunology, Robert-Debré Hospital, Assistance Publique-Hôpitaux de Paris AP-HP, 75019, Paris, France.

Pediatric Research
|April 1, 2019
PubMed

Insights

Cytokine production shifts from high IL-10 in newborns to balanced levels in infants, crucial for fighting infection and preventing inflammation. This developmental change is key to immune system maturation.

Area of Science:

  • Immunology
  • Developmental Biology
  • Pediatrics

Background:

  • Altered cytokine production is linked to childhood susceptibility to infections.
  • Understanding cytokine response development is crucial for pediatric health.

Purpose of the Study:

  • To investigate developmental patterns of cytokine responses from birth to adulthood.
  • To gain insight into immune system maturation in early life.

Main Methods:

  • Compared expression levels of 13 cytokines in phytohemagglutinin (PHA)-stimulated whole blood.
  • Analyzed samples from neonates, infants, and school-aged children, with adults as reference.

Main Results:

  • Th1, Th2, and Th17 cytokine levels increased from birth to childhood.
  • High IL-10 secretion at birth decreased significantly in infants, with a shift in IL-10 correlation.
  • IL-2, IL-7, and Granulocyte-Colony Stimulating Factor (G-CSF) levels decreased in the first year of life.

Conclusions:

  • A rapid shift from high IL-10 to balanced IL-10/Th1/Th2/Th17 cytokine levels occurs early in life.
  • This transition is essential for effective pathogen defense and regulation of inflammatory responses.
Abstract

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