Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Isoniazid hepatotoxicity in children.

R S Rapp, R W Campbell, J C Howell

    The American Review of Respiratory Disease
    |October 1, 1978
    PubMed
    Summary

    Isoniazid therapy for tuberculous infection in children showed no signs of liver damage. This study found the treatment safe and effective, with no need to stop therapy due to adverse effects.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Cerebrospinal fluid biomarkers in Parkinson's disease with freezing of gait: an exploratory analysis.

    NPJ Parkinson's disease·2021
    Same author

    [Validation of Personal Factors in Breast Cancer Rehabilitation - A National Delphi Survey].

    Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany))·2016
    Same author

    Poor growth, thyroid dysfunction and vitamin D deficiency remain prevalent despite reduced intensity chemotherapy for hematopoietic stem cell transplantation in children and young adults.

    Bone marrow transplantation·2016
    Same author

    Oxytetracycline in the treatment of pinworm infestation.

    Antibiotics & chemotherapy (Northfield, Ill.)·2014
    Same author

    Photon-counting compressive sensing laser radar for 3D imaging.

    Applied optics·2011
    Same author

    Experimental violation of two-party Leggett-Garg inequalities with semiweak measurements.

    Physical review letters·2011

    Area of Science:

    • Pediatrics
    • Infectious Diseases
    • Hepatology

    Background:

    • Tuberculous infection is a significant global health concern in children.
    • Isoniazid is a primary treatment for tuberculous infection, but potential hepatotoxicity requires monitoring.

    Purpose of the Study:

    • To evaluate the safety and hepatotoxicity of isoniazid therapy in pediatric patients.
    • To assess liver enzyme levels and clinical symptoms during isoniazid treatment.

    Main Methods:

    • Serum glutamic oxaloacetic transaminase (SGOT) levels were measured in 116 children at baseline, mid-treatment, and post-treatment.
    • Children included 50 individuals under 10 years of age.
    • Clinical monitoring for adverse effects was conducted throughout the therapy course.

    Main Results:

    • No evidence of hepatotoxicity was observed based on SGOT levels in any of the children studied.
    • No clinical symptoms necessitating discontinuation of isoniazid therapy were reported.
    • Liver enzyme levels remained within normal ranges during and after treatment.

    Conclusions:

    • Isoniazid therapy is a safe and well-tolerated treatment for tuberculous infection in children.
    • The risk of hepatotoxicity appears minimal in pediatric patients undergoing isoniazid treatment.
    • Continued monitoring and adherence to treatment protocols are recommended for managing childhood tuberculosis.

    Related Experiment Videos