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Isoniazid hepatotoxicity in children
The American Review of Respiratory Disease
|October 1, 1978
Insights
Isoniazid therapy for tuberculous infection in children showed no signs of liver damage. This study found the treatment safe and effective, with no need to stop therapy due to adverse effects.
Area of Science:
- Pediatrics
- Infectious Diseases
- Hepatology
Background:
- Tuberculous infection is a significant global health concern in children.
- Isoniazid is a primary treatment for tuberculous infection, but potential hepatotoxicity requires monitoring.
Purpose of the Study:
- To evaluate the safety and hepatotoxicity of isoniazid therapy in pediatric patients.
- To assess liver enzyme levels and clinical symptoms during isoniazid treatment.
Main Methods:
- Serum glutamic oxaloacetic transaminase (SGOT) levels were measured in 116 children at baseline, mid-treatment, and post-treatment.
- Children included 50 individuals under 10 years of age.
- Clinical monitoring for adverse effects was conducted throughout the therapy course.
Main Results:
- No evidence of hepatotoxicity was observed based on SGOT levels in any of the children studied.
- No clinical symptoms necessitating discontinuation of isoniazid therapy were reported.
- Liver enzyme levels remained within normal ranges during and after treatment.
Conclusions:
- Isoniazid therapy is a safe and well-tolerated treatment for tuberculous infection in children.
- The risk of hepatotoxicity appears minimal in pediatric patients undergoing isoniazid treatment.
- Continued monitoring and adherence to treatment protocols are recommended for managing childhood tuberculosis.
Abstract:
One hundred sixteen children, including 50 less than 10 years of age, received isoniazid therapy for tuberculous infection. Determinations of serum glutamic oxaloacetic transaminase concentrations at time of institution of therapy, 6 to 20 weeks later, and again at the completion of the therapeutic course, showed no evidence of hepatotoxicity. Clinical symptoms were never such that discontinuation of therapy was necessary.