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Related Concept Videos

Kendall's Tau Test01:16

Kendall's Tau Test

1.2K
Kendall's tau test, also known as the Kendall rank coefficient test, is a nonparametric method for assessing association between two variables. This test is particularly useful for identifying significant correlations when the distributions of the sample and population are unknown. Developed in 1938 by the British statistician Sir Maurice George Kendall, the tau coefficient (denoted as τ) serves as a rank correlation coefficient, with values ranging from -1 to +1.
A τ value of +1 indicates...
1.2K

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Patient-derived forebrain cortical organoids reveal biphasic tau-MAP6-microtubule axis dysfunction in tauopathy.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
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Related Experiment Video

Updated: Jan 27, 2026

In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein
09:22

In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein

Published on: January 2, 2015

19.0K

Tau: It's Not What You Think.

Peter W Baas1, Liang Qiang1

  • 1Drexel University College of Medicine, Department of Neurobiology and Anatomy, 2900 Queen Lane, Philadelphia, PA 19129, USA.

Trends in Cell Biology
|April 2, 2019
PubMed
Summary

The protein tau

Area of Science:

  • Neuroscience
  • Cell Biology

Background:

  • The protein tau has long been considered a microtubule stabilizer in neurons.
  • This long-held belief was primarily based on in vitro studies and non-neuronal cell experiments.

Purpose of the Study:

  • To re-evaluate the established role of tau in axonal microtubule dynamics.
  • To challenge the prevailing dogma regarding tau's function in neuronal axons.

Main Methods:

  • The study likely involved advanced imaging techniques and genetic manipulation in neuronal models.
  • Analysis of microtubule behavior and tau's interaction under physiological conditions.

Main Results:

  • Recent findings suggest tau does not stabilize axonal microtubules.
  • Instead, tau appears to promote long, labile microtubule domains by inhibiting other stabilizers.
Keywords:
Alzheimer’s diseaseMAP6axonmicrotubulemicrotubule stabilityneuron

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Conclusions:

  • The traditional view of tau as a microtubule stabilizer is challenged.
  • A revised understanding of tau's function is crucial for neurological disease research.