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Updated: Jan 27, 2026

Development and Assessment of Intracellular Infection Models for Staphylococcus aureus
Published on: January 17, 2025
[Endogenous endophthalmitis following staphylococcus aureus meningitis]
Chigusa Shirakawa1, Chie Yanagihara1, Shin Takano1
1Division of Neurology, Nishi-Kobe Medical Center.
Abstract:
Endogenous endophthalmitis is a rare complication of acute meningitis. A healthy 82-year-old woman suddenly developed septic bacteremia and meningitis owing to Staphylococcus aureus (methicillin-susceptible Staphylococcus aureus); she presented with a high fever and drowsiness. Improvement of these initial symptoms unveiled impaired bilateral visual acuity. Detailed ophthalmological assessments diagnosed it as probable endogenous endophthalmitis, which was immediately treated with vitrectomy. Subsequently, the patient totally recovered without any neurologic or ophthalmic sequela.
Insights
Endogenous endophthalmitis, a rare complication of meningitis, can cause vision loss. Prompt vitrectomy treatment in this case led to a full recovery of both neurological and ophthalmic functions.
Area of Science:
- Ophthalmology
- Infectious Diseases
- Neurology
Background:
- Endogenous endophthalmitis is an uncommon but serious complication of bacterial meningitis.
- Staphylococcus aureus bacteremia can lead to severe systemic infections, including meningitis.
Observation:
- An 82-year-old woman with Staphylococcus aureus meningitis presented with fever and drowsiness.
- Following initial improvement, she developed bilateral decreased visual acuity, suggesting ocular involvement.
Findings:
- Ophthalmological examination confirmed probable endogenous endophthalmitis in both eyes.
- The patient underwent prompt surgical intervention with vitrectomy.
Implications:
- Early diagnosis and treatment of endogenous endophthalmitis are crucial for visual recovery.
- This case highlights the importance of comprehensive assessment in patients with severe infections.
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