Symptoms-modifying effects of electromotive administration of glucosamine sulphate among patients with knee
Ayodele Teslim Onigbinde1, Adegbenga Rotimi Owolabi2, Kamil Lasisi3
1Department of Medical Rehabilitation, Faculty of Basic Medical Sciences College of Health Sciences, Obafemi Awolowo University Ile-Ife, Osun State, Nigeria.
Background:
Most trials on symptom-modifying effects of glucosamine are limited to administration through oral route with dearth of empirical data on the use of electromotive force.
Objective:
The study determined the effects of glucosamine sulphate (GS) iontophoresis (IoT) on radiographic parameters of patients with knee osteoarthritis (OA).
Methods:
Fifty-three patients were randomly assigned to three groups. About 1 g each of GS was administered using IoT and cross-friction massage (CFM) for participants in groups 1 (IoT) and 2 (CFM), respectively. Group 3 ((Combined therapy) CoT) received 1 g of GS using both IoT and CFM. Interventions were twice a week for 12 weeks. Analysis of variance (ANOVA) was used to analyze the data ( ).
Results:
After 12 weeks, the medial joint space width (JSW) of the CFM group was significantly higher than that of IoT and CoT groups ( and ). Lateral JSW of IoT group was significantly higher than both CFM ( ) and CoT groups ( ). There were significant decreases in pain intensities; increase in knee flexion and physical functions across the groups ( ; , respectively).
Conclusion:
It was concluded that there were significant decreases in the degenerative changes at the knee joint.
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