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Updated: Jan 27, 2026

Murine Model of Intestinal Ischemia-reperfusion Injury
Published on: May 11, 2016
Positive acceleration adaptive training attenuates gastric ischemia-reperfusion injury through COX-2 and PGE2
Ying Chen1, Jian-Chang Wang1, Chun-Min Yang1
1Department of Gastroenterology and Research Center of Aeropathy, General Hospital of The Air Force, People's Liberation Army, Beijing 100036, P.R. China.
Abstract:
The mechanism involved in the effects of positive acceleration adaptive training (PAAT) on gastric ischemia-reperfusion injury (GI-RI) has not been fully characterized. The aim of the present study was to investigate the effects of PAAT in attenuating GI-RI in a rat model. The inflammatory factor and caspase-3 levels were measured using ELISA kits. A western blot assay was used to analyze tumor necrosis factor-α (TNF)-α, tumor necrosis factor receptor 1 (TNFR1), tumor necrosis factor-related apoptosis inducing ligand (TRAIL), death receptor (DR) 4, DR5, cyclooxygenase (COX)-2, COX-1 and prostaglandin E2 (PGE2) protein expression levels. It was revealed that PAAT could alleviate GI-RI and inflammatory factor levels in a rat model. PAAT suppressed TNF-α and TNFR1 protein expression levels, inhibited TRAIL, DR4, DR5, COX-2 and PGE2 protein expression levels; however, it did not have an effect on COX-1 protein expression in the model of GI-RI. The data indicated that the effects of PAAT attenuated GI-RI through the downregulation of COX-2 and PGE2 expression.
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