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Association of Matrix Metalloproteinase 9 (MMP-9) Polymorphisms with Asthma Risk: A Meta-Analysis

Fenfang Zou1, Jianpeng Zhang1, Guoan Xiang1

  • 1Department of Respiratory, The Third Medical Center of Chinese People's Liberation Army General Hospital, Beijing, China.

Canadian Respiratory Journal
|April 2, 2019
PubMed

Insights

This meta-analysis found no significant link between MMP-9 -1562 C>T polymorphism and asthma. However, the MMP-9 Arg668Gln, rs17577 polymorphism may be a risk factor for asthma susceptibility.

Area of Science:

  • Genetics
  • Immunology
  • Respiratory Medicine

Background:

  • Matrix metalloproteinase-9 (MMP-9) plays a role in inflammatory processes.
  • Published data on MMP-9 polymorphisms and asthma susceptibility are inconclusive.
  • A comprehensive meta-analysis is needed for a precise estimation of the association.

Purpose of the Study:

  • To investigate the association between MMP-9 polymorphisms (-1562 C>T, rs3918242; Gln279Arg, rs17576; Arg668Gln, rs17577) and asthma susceptibility.
  • To provide a more precise estimation of these associations through meta-analysis.

Main Methods:

  • A systematic literature search was conducted in multiple databases (PubMed, Web of Science, EMBASE, Wanfang, CNKI).
  • Eligible studies involving asthma patients and controls were identified.
  • Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated, and sensitivity analyses and publication bias tests were performed.

Main Results:

  • No significant association was found between the MMP-9 -1562 C>T (rs3918242) polymorphism and asthma susceptibility across all genetic models and subgroups.
  • A potential borderline significant association was observed for the Gln279Arg (rs17576) polymorphism in the allelic model (OR=1.11, 95% CI=1.00-1.22).
  • A highly significant association was observed for the Arg668Gln (rs17577) polymorphism in dominant, recessive, homozygote genotype, and allelic models, suggesting it as a risk factor.

Conclusions:

  • The MMP-9 -1562 C>T (rs3918242) polymorphism is not associated with asthma susceptibility.
  • The MMP-9 Arg668Gln (rs17577) polymorphism may represent a risk factor for asthma susceptibility.
  • Further research may be warranted to elucidate the role of specific MMP-9 polymorphisms in asthma pathogenesis.

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