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Dupuytren's disease: where do we stand?
Rita Grazina1, Sérgio Teixeira2, Renato Ramos1
1Serviço de Ortopedia e Traumatologia, Centro Hospitalar Vila Nova de Gaia/Espinho, Portugal.
EFORT Open Reviews
|April 2, 2019
Summary
Dupuytren's disease causes hand contractures due to abnormal collagen. This review summarizes current knowledge on its causes and varied treatment approaches for this common fibroproliferative disorder.
Area of Science:
- Orthopedics
- Hand Surgery
- Fibroproliferative Disorders
Background:
- Dupuytren's disease is a fibroproliferative condition characterized by collagen deposition.
- It leads to hand contractures, impacting hand mobility and grip strength, causing significant morbidity.
- Potential etiological factors include genetics, smoking, alcohol, and diabetes, though the primary cause remains debated.
Purpose of the Study:
- To review the pathogenesis of Dupuytren's disease.
- To summarize current treatment options and the state-of-the-art.
- To address the controversies surrounding the disease's etiology.
Main Methods:
- Literature review of existing studies on Dupuytren's disease.
- Synthesis of information on disease mechanisms.
- Compilation of data on various treatment modalities.
Main Results:
- The review consolidates current understanding of Dupuytren's disease pathogenesis.
- It highlights the variability in global treatment strategies.
- The review underscores the ongoing debate regarding etiological factors.
Conclusions:
- Dupuytren's disease pathogenesis and etiology require further elucidation.
- Standardization of treatment approaches is needed.
- This review provides a comprehensive overview for clinicians and researchers.