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Tissue Response to Subcutaneous Infusion Catheter.

Ershuai Zhang1, Zhiqiang Cao1

  • 1Department of Chemical Engineering and Materials Science, Wayne State University, Detroit, MI, USA.

Journal of Diabetes Science and Technology
|April 2, 2019
PubMed
Summary

Insulin infusion sets (IIS) for type 1 diabetes require more research. Current IIS wear time limits integration with continuous glucose monitoring (CGM) and can cause skin issues, impacting therapy adherence.

Keywords:
continuous subcutaneous insulin infusioninfusion catheterinsulin infusion setskin complicationstissue responsetype 1 diabetes

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Area of Science:

  • Endocrinology
  • Biomedical Engineering
  • Dermatology

Background:

  • Insulin infusion pumps, continuous glucose monitoring (CGM), and insulin infusion sets (IIS) are advancing for type 1 diabetes (T1D) management.
  • CGM wear times are increasing, but IIS wear time remains limited to 2-3 days.
  • IIS complications can negatively affect glycemic control, increase hypoglycemia risk, and impact user adherence to insulin pump therapy.

Purpose of the Study:

  • To systematically review subcutaneous tissue responses and skin complications associated with insulin infusion sets (IIS).
  • To analyze the impact of inserted catheters, infused insulin, and fixation materials on infusion sites.
  • To discuss FDA recommendations for IIS changes and identify areas for future research and development.

Main Methods:

  • Systematic literature review of studies on IIS-induced subcutaneous tissue responses and skin complications.
  • Analysis of factors contributing to infusion site reactions, including catheter material, insulin properties, and adhesives.
  • Discussion of current guidelines and regulatory recommendations for IIS usage.

Main Results:

  • Limited research exists on IIS-induced complications, despite their impact on T1D management.
  • Potential complications include tissue reactions and skin issues at the infusion site.
  • Short IIS wear time hinders the development of closed-loop systems and impacts therapy acceptance.

Conclusions:

  • Further research is crucial to understand and mitigate IIS-related subcutaneous tissue responses and skin complications.
  • Developing strategies to extend IIS wear time and improve site management is essential.
  • Enhancing IIS technology and user education can improve insulin pump therapy acceptance and outcomes for individuals with T1D.