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Hemodynamic Precision in the Neonatal Intensive Care Unit using Targeted Neonatal Echocardiography
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Conventional intensive versus LED intensive phototherapy oxidative stress burden in neonatal hyperbilirubinaemia of

Wesam A Mokhtar1, Laila M Sherief1, Hany Elsayed1

  • 1Pediatric Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Paediatrics and International Child Health
|April 2, 2019
PubMed

Insights

Intensive light-emitting diode (LED) phototherapy is safer than conventional phototherapy for treating neonatal jaundice, effectively reducing bilirubin levels while minimizing oxidative stress and adverse effects. This finding is crucial for improving neonatal care and infant health outcomes.

Area of Science:

  • Neonatal Medicine
  • Biochemistry
  • Phototherapy Research

Background:

  • Neonates are susceptible to oxidative stress, particularly during phototherapy for hyperbilirubinaemia.
  • Phototherapy can exacerbate oxidative damage in neonatal red blood cell membranes.

Purpose of the Study:

  • To compare the effects of conventional and LED phototherapy on oxidant/antioxidant status in neonates with haemolytic hyperbilirubinaemia.
  • To evaluate the safety and efficacy of different intensive phototherapy light sources.

Main Methods:

  • A randomized controlled study involving 54 neonates with indirect haemolytic hyperbilirubinaemia.
  • Infants received either conventional phototherapy or intensive LED phototherapy.
  • Measurements included total serum bilirubin (TSB), total oxidative stress (TOS), total antioxidant capacity (TAC), and oxidative stress index (OSI) before and after treatment.

Main Results:

  • Both phototherapy methods significantly decreased TSB.
  • LED phototherapy showed a less pronounced increase in TOS and OSI compared to conventional phototherapy.
  • Conventional phototherapy led to a greater decrease in TAC and increased adverse effects like dehydration and hyperthermia.

Conclusions:

  • Intensive LED phototherapy is a safer alternative to conventional phototherapy for neonatal jaundice.
  • LED phototherapy effectively reduces TSB with a better safety profile regarding oxidative stress and adverse events.

Keywords:
Conventional intensive phototherapyLED intensive phototherapyhaemolysishyperbilirubinaemianeonateoxidative stress

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