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Heat Shock Protein 70 kDa as a Target for Diagnostics and Therapy of Cardiovascular and Cerebrovascular Diseases

Ekaterina V Konstantinova1, Natalia S Chipigina1, Marina H Shurdumova1

  • 1Pirogov Russian National Research Medical University, Ulitsa Ostrovityanova, 1, Moskva, Russian Federation.

Current Pharmaceutical Design
|April 2, 2019
PubMed

Insights

Heat shock protein 70 (HSP70) increases during ischemia, offering cell protection. Elevated HSP70 in patients suggests its potential for diagnosing and treating cardiovascular and cerebrovascular diseases.

Area of Science:

  • Biomedical Science
  • Molecular Biology
  • Pathophysiology

Background:

  • Acute focal ischemia is a key factor in cardiovascular and cerebrovascular diseases like myocardial infarction and stroke.
  • Ischemia triggers a significant increase in intracellular heat shock proteins (HSPs), particularly HSP70, across various cell types.
  • HSP70 exhibits cytoprotective properties, enhancing cell survival and inhibiting programmed cell death under stress.

Purpose of the Study:

  • To review the role of HSP70 in cellular responses to ischemia.
  • To explore the diagnostic and therapeutic potential of HSP70 in cardiovascular and cerebrovascular diseases.

Main Methods:

  • Literature review of studies on HSP70 expression and function during ischemia.
  • Analysis of clinical data showing HSP70 levels in patients with ischemic conditions.

Main Results:

  • HSP70 levels rise in cardiomyocytes and brain cells during ischemia, correlating with cardioprotective and neuroprotective effects.
  • Elevated HSP70 has been observed in peripheral blood lymphocytes of patients with ischemic stroke and myocardial infarction.
  • HSP70 demonstrates significant cytoprotective functions, aiding cell survival and preventing apoptosis.

Conclusions:

  • HSP70 plays a crucial role in cellular defense against ischemic injury.
  • Elevated HSP70 in peripheral blood may serve as a biomarker for ischemic events.
  • HSP70 represents a promising therapeutic target for managing cardiovascular and cerebrovascular diseases.

Keywords:
Heat shock proteinsatherosclerosiscerebral ischemiaimmunomodulatory activitiesischemic strokemyocardial infarction.

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