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Related Experiment Videos

Human milk does not degrade TRH.

R Angyal, V Strbák

    Endocrinologia Experimentalis
    |August 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Human milk does not degrade thyrotropin-releasing hormone (TRH). This suggests TRH in milk may play a physiological role for newborns, as milk lacks TRH-degrading enzymes.

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    Area of Science:

    • Endocrinology
    • Neonatal Physiology
    • Biochemistry

    Background:

    • Thyrotropin-releasing hormone (TRH) is biologically active in rat milk.
    • High concentrations of TRH are found in human milk.
    • Newborns lack TRH-degrading activity in their plasma.

    Purpose of the Study:

    • To investigate the TRH-degrading activity of human milk.
    • To determine if human milk contains enzymes that degrade TRH.
    • To assess the potential physiological role of milk-borne TRH in neonates.

    Main Methods:

    • In vitro incubation of TRH with human milk samples (collected 4 days and 4 months postpartum).
    • Assay of TRH degradation using radioimmunoassay (RIA).
    • Incubation of TRH with human milk and adult human plasma.

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    Main Results:

    • TRH was not degraded when incubated with human milk for 2 hours.
    • Human milk did not inhibit TRH degradation in adult human plasma.
    • No significant TRH degradation was observed in the presence of human milk.

    Conclusions:

    • Human milk lacks enzymes capable of degrading TRH.
    • Human milk does not contain inhibitors of TRH-degrading enzymes.
    • The stability of TRH in human milk supports its potential physiological role in newborns.