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Published on: April 12, 2019
Three new polyketides from a mangrove-derived fungus Colletotrichum gloeosporioides
You-Ping Luo1,2, Cai-Juan Zheng1,2, Guang-Ying Chen3,4
1Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, 571158, Haikou, People's Republic of China.
Abstract:
Three new polyketides, (2S)-2,3-dihydro-5,6-dihydroxy-2-methyl-4H-1-benzopyran-4-one (1), (2'R)-2-(2'-hydroxypropyl)-4-methoxyl-1,3-benzenediol (2), and 4-ethyl-3-hydroxy-6-propenyl-2H-pyran-2-one (3) were isolated from the culture broth of Colletotrichum gloeosporioides, an endophytic fungus derived from the mangrove Ceriops tagal. The structures of 1-3 were elucidated on the basis of NMR spectra and HR-ESI-MS data. Their absolute configurations were determined by comparing with the experimental and calculated ECD spectrum. Compounds 1 and 3 showed potent antibacterial activities against some of the tested microbes.
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