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Updated: Jan 27, 2026

Physical, Chemical and Biological Characterization of Six Biochars Produced for the Remediation of Contaminated Sites
Published on: November 28, 2014
Minor structural modifications to Pracinostat produce big changes in its biological responses
Rong Jia1, Pengju Sun1, Yan Zhang1
1Institute of Molecular Design and Drug Discovery, School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, China.
Abstract:
A series of compounds similar to Pracinostat that contained benzimidazole ring and N-hydroxyacrylamide attached at 5- or 6-position were designed, synthesized, and evaluated as HDAC inhibitors. It was interesting to find that the corresponding derivative 1 with N-hydroxyacrylamide attached at 5-position was a potent HDAC inhibitor while the others at 6-position were not. This is the first time to demonstrate the position difference plays important role in the HDAC inhibitory activities of the cinnamic hydroxamates.
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