[Antiaggregation action and pharmacokinetics of lysine acetylsalicylate]

Lysine acetylsalicylate, a water-soluble salt of acetylsalicylic acid, administered intravenously to rabbits (15 and 100 mg/kg) and also in vitro (2-10 mg/ml) produced antiaggregational and anticoagulant effects pertaining to acetylsalicylic acid. Pharmacokinetics of acetylsalicylic acid injected intravenously to rabbits in the form of lysine acetylsalicylate is formalized by a biexponential equation for a two-compartment model. The main pharmacokinetic constants of acetylsalicylic acid in these experiments were found to be similar to those in humans.