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Low absolute NK cell counts in peripheral blood are associated with inferior survival in patients with mantle cell

Xiao-Hui Zhou1,2,3,1, Xin-Yu Zhang1,2,3,1, Jin-Hua Liang1,2,3

  • 1Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, Jiangsu 210029, China.

Cancer Biomarkers : Section a of Disease Markers
|April 2, 2019
PubMed
Abstract

Insights

Low absolute natural killer cell counts (ANKC) predict worse overall survival in mantle cell lymphoma (MCL) patients. This finding offers new insights for risk stratification beyond the simplified MCL International Prognostic Index (sMIPI).

Area of Science:

  • Hematology
  • Oncology
  • Immunology

Background:

  • Mantle cell lymphoma (MCL) risk stratification typically uses the simplified MCL International Prognostic Index (sMIPI).
  • Host-related factors and tumor microenvironment, including absolute monocyte counts (AMC) and T lymphocyte subsets, are increasingly recognized as critical for MCL prognosis.
  • Absolute natural killer cell counts (ANKC) are a potential prognostic marker in MCL.

Purpose of the Study:

  • To investigate the impact of peripheral blood ANKC and AMC at diagnosis on MCL prognosis.
  • To determine if ANKC and AMC can improve risk stratification in MCL.

Main Methods:

  • Retrospective study of 92 newly diagnosed MCL patients.
  • Flow cytometric analysis of fresh peripheral blood samples to determine ANKC and AMC.
  • Univariable and multivariable analyses to assess prognostic significance.

Main Results:

  • Median follow-up was 42 months; median overall survival (OS) was 45 months.
  • High AMC was associated with inferior progression-free survival (PFS) and OS in univariable analysis.
  • Low ANKC was significantly associated with worse OS in both univariable and multivariable analyses, independent of sMIPI.

Conclusions:

  • Low ANKC (≤ 0.1 × 10^9/L) is a significant predictor of inferior OS in MCL patients.
  • ANKC may serve as a valuable prognostic biomarker for MCL, complementing existing risk scores like sMIPI.
Keywords:
Mantle cell lymphomaabsolute monocyte countsabsolute natural killer cell countsprognosis

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