Related Experiment Video
Updated: Jan 27, 2026
04:38
A Murine Tail Lymphedema Model
Published on: February 10, 2021
6.6K
Prostate-Specific Membrane Antigen Accumulation in Lower Extremity Lymphedema
Jingjing Zhang1, Harshad R Kulkarni, Aviral Singh
1From the THERANOSTICS Center for Molecular Radiotherapy and Precision Oncology, Bad Berka, Germany.
Clinical Nuclear Medicine
|April 2, 2019
Summary
Lutetium-labeled prostate-specific membrane antigen (Lu-PSMA) therapy for prostate cancer revealed unexpected soft-tissue uptake in the lower extremity. Post-treatment imaging showed dermal backflow, indicating a potential complication of metastatic lymph node-related lymphedema.
Area of Science:
- Oncology
- Nuclear Medicine
- Radiopharmaceutical Therapy
Background:
- Prostate-specific membrane antigen (PSMA) is a validated target in prostate cancer.
- PSMA-targeted radioligands are used for both diagnostic imaging and targeted radionuclide therapy.
- Lutetium-177 (Lu) labeled PSMA (Lu-PSMA) offers therapeutic beta emission and imaging gamma radiation for dosimetry and biodistribution assessment.
Observation:
- A patient with prostate cancer and metastatic lymph node-induced lower extremity lymphedema received intravenous Lu-PSMA treatment.
- Post-treatment whole-body imaging was performed to assess the radioligand's distribution and uptake.
- The scan revealed dermal backflow and soft-tissue uptake in the affected lower extremity.
Findings:
- The post-therapeutic whole-body scan demonstrated unexpected Lu-PSMA uptake in the soft tissues of the lower extremity.
- This uptake correlated with the clinical presentation of lymphedema.
- Dermal backflow was also observed, indicating abnormal lymphatic drainage.
Implications:
- Post-therapeutic imaging with Lu-PSMA can identify and characterize lymphedema in prostate cancer patients.
- This imaging modality may serve as a biomarker for lymphatic dysfunction related to metastatic disease.
- Understanding PSMA uptake patterns in non-target tissues like the lymphatic system can refine treatment strategies and improve patient outcomes.
More Related Videos
Related Concept Videos
01:22Absolute and Local Extreme Values
59
The highest and lowest values of a function, relative to a reference axis, are known as extreme values. These include absolute maximum and absolute minimum values, which represent the highest and lowest points the function reaches across its entire domain. Within a restricted portion of the function, the highest and lowest values are referred to as local maximum and local minimum values, respectively.Periodic functions, such as sine and cosine, show extreme values at infinitely many points due...
59
01:16Specific Heat
67.3K
The specific heat capacity of a substance refers to the energy required to increase the temperature of one gram of that substance by one degree Celcius. Specific heat capacity is often represented in calories (cal), grams (g), and degrees Celsius (oC), but can also be expressed in joules (J), kilograms (kg), and Kelvin (K), among other units.
For example, increasing the temperature of one gram of water by 1°C requires one calorie of heat energy and can be written as 1 cal/g-°C, or...
For example, increasing the temperature of one gram of water by 1°C requires one calorie of heat energy and can be written as 1 cal/g-°C, or...
67.3K
01:21Drug Accumulation During Multiple Dosing: Repetitive IV Injections
266
Calculating drug dosage and accumulation in multiple-dose regimens is crucial for achieving therapeutic efficacy while avoiding toxicity. This involves determining the plasma drug concentrations over time to optimize dosing schedules. The principle of superposition is fundamental in this process, allowing for the prediction of drug concentration in plasma following multiple doses based on single-dose data.The principle of superposition asserts that the plasma concentration-time curves from...
266
01:24Drug Accumulation During Multiple Dosing: Intermittent IV Infusions
240
Intermittent intravenous (IV) infusion is a method of drug administration where medications are delivered over short infusion periods followed by intervals of no drug delivery. This approach helps to prevent sustained high drug concentrations in the bloodstream, reducing the risk of adverse effects associated with prolonged exposure. Unlike continuous infusion, steady-state concentrations may not be achieved during a single dosing cycle but can be reached through repeated...
240
01:22Antigen Presenting Cells
3.1K
The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
3.1K
01:28Diversity of Antigen Receptors
1.4K
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
1.4K