Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Sound Intensity00:58

Sound Intensity

4.7K
The loudness of a sound source is related to how energetically the source is vibrating, consequently making the molecules of the propagation medium vibrate. To measure the loudness of a source, the physical quantity of interest is the intensity. This is defined as the energy emitted per unit of time per unit of area perpendicular to the sound wave's propagation direction. Since the total energy is greater if the source vibrates for a longer duration and over a larger area, dividing the...
4.7K
Seedless Vascular Plants03:24

Seedless Vascular Plants

66.7K
Seedless Vascular Plants Were the First Tall Plants on Earth
66.7K
Sound Intensity Level00:53

Sound Intensity Level

4.8K
Humans perceive sound by hearing. The human ear helps sound waves reach the brain, which then interprets the waves and creates the perception of hearing. The loudness of the environment in which a person is located determines whether they can distinguish between different sound sources.
The human ear can perceive an extensive range of sound intensity, necessitating the use of the logarithmic scale to define a physical quantity—the intensity level. It is a ratio of two intensities and...
4.8K
Exercise Stress Test01:26

Exercise Stress Test

1.3K
Introduction
Exercise stress testing, commonly known as a treadmill test, is a noninvasive procedure used to evaluate cardiovascular function and diagnose heart conditions.
Definition
An exercise stress test measures the heart's response to exertion using a treadmill or stationary bicycle. Chest electrodes record the heart's electrical activity through an ECG, and blood pressure is monitored regularly.
Purposes
1.3K
Intensity Of Electromagnetic Waves01:22

Intensity Of Electromagnetic Waves

5.8K
The energy transport per unit area per unit time, or the Poynting vector, gives the energy flux of an electromagnetic wave at any specific time. For a plane electromagnetic wave with E0 and B0 as the peak electric and magnetic fields and traveling along the x-axis, the time-varying energy flux can be given by the following equation:
5.8K
Exercise and Muscle Performance01:27

Exercise and Muscle Performance

2.3K
Exercise induces a range of adaptations in muscle tissue, depending on the type and duration of activity. Such physical training can be broadly categorized into two types: endurance exercises and resistance exercises.
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
2.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Performance determinants in Ski mountaineering sprint: data from the pre-2026 Olympic test event.

Frontiers in sports and active living·2026
Same author

CAROTID BODY CHEMORECEPTORS: FROM MOUNTAIN TO SPACE.

Physiology (Bethesda, Md.)·2026
Same author

Common and Divergent Physiological Responses to Hypoxia and Heat.

Sports medicine (Auckland, N.Z.)·2026
Same author

Acute effects of "Munz Floor"® fascial stretching on autonomic nervous responses assessed by heart rate variability.

Frontiers in physiology·2026
Same author

Beyond single stressors/stimuli in adaptive physiology: Dose-response relationships and translational challenges.

Experimental physiology·2026
Same author

Exogenous ketosis does not alter oxygenation, oxygen uptake kinetics, or whole-body efficiency during submaximal exercise in early high-altitude acclimatization.

Journal of applied physiology (Bethesda, Md. : 1985)·2026

Related Experiment Video

Updated: Jan 27, 2026

Supramaximal Intensity Hypoxic Exercise and Vascular Function Assessment in Mice
10:00

Supramaximal Intensity Hypoxic Exercise and Vascular Function Assessment in Mice

Published on: March 15, 2019

8.9K

Supramaximal Intensity Hypoxic Exercise and Vascular Function Assessment in Mice.

Jessica Lavier1, Manon Beaumann2, Steeve Ménetrey2

  • 1Division of Angiology, Heart and Vessel Department, Lausanne University Hospital (CHUV); Institute of Sport Sciences, Faculty of Biology and Medicine, University of Lausanne; jessica.lavier@unil.ch.

Journal of Visualized Experiments : Jove
|April 2, 2019
PubMed
Summary

This study details a method for combining supramaximal exercise training with hypoxia in mice. This approach allows for the assessment of vascular function, potentially aiding in the development of new treatments for cardiovascular diseases.

More Related Videos

Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training
07:40

Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training

Published on: October 10, 2019

7.7K
Short Session High Intensity Interval Training and Treadmill Assessment in Aged Mice
09:19

Short Session High Intensity Interval Training and Treadmill Assessment in Aged Mice

Published on: February 2, 2019

10.5K

Related Experiment Videos

Last Updated: Jan 27, 2026

Supramaximal Intensity Hypoxic Exercise and Vascular Function Assessment in Mice
10:00

Supramaximal Intensity Hypoxic Exercise and Vascular Function Assessment in Mice

Published on: March 15, 2019

8.9K
Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training
07:40

Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training

Published on: October 10, 2019

7.7K
Short Session High Intensity Interval Training and Treadmill Assessment in Aged Mice
09:19

Short Session High Intensity Interval Training and Treadmill Assessment in Aged Mice

Published on: February 2, 2019

10.5K

Area of Science:

  • Exercise physiology
  • Cardiovascular research
  • Animal models

Background:

  • Exercise training is crucial for health and chronic disease prevention, especially for cardiovascular diseases like lower extremity artery disease.
  • Current exercise protocols include continuous and interval training, with supramaximal training showing promise for athletic performance through vascular adaptations.
  • Combining supramaximal training with hypoxia may offer synergistic benefits for specific pathologies.

Purpose of the Study:

  • To describe a methodology for performing supramaximal intensity exercise training in hypoxia on healthy mice.
  • To outline procedures for dissecting key vascular tissues, including the pulmonary artery, abdominal aorta, and iliac artery.
  • To demonstrate ex vivo assessment of vascular function using isometric tension studies on retrieved vessels.

Main Methods:

  • Utilized a motorized treadmill and hypoxic box to conduct supramaximal training (150% maximal speed) in a hypoxic environment.
  • Developed protocols for precise dissection of pulmonary, abdominal aorta, and iliac arteries from mice.
  • Employed isometric tension studies for ex vivo functional assessment of isolated blood vessels.

Main Results:

  • Successfully established a protocol for supramaximal exercise training under hypoxic conditions in mice.
  • Demonstrated the feasibility of retrieving and preparing specific arteries for subsequent functional analysis.
  • Provided a framework for evaluating vascular responses to combined supramaximal exercise and hypoxia.

Conclusions:

  • The described methodology enables the investigation of supramaximal exercise and hypoxia effects on vascular function in a controlled animal model.
  • This approach can be valuable for understanding underlying mechanisms and exploring therapeutic strategies for cardiovascular conditions.
  • Further research can build upon this protocol to elucidate the specific vascular adaptations induced by this training regimen.