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The effect of curcumin on healing in an animal nasal septal perforation model

Doğan Çakan1, Sedat Aydın1, Gökhan Demir2

  • 1Ear, Nose, and Throat Department, University of Health Sciences Kartal Dr Lütfi Kirdar Hospital, Istanbul, Turkey.

The Laryngoscope
|April 2, 2019
PubMed
Abstract

Insights

Topical curcumin significantly enhanced nasal septum wound healing in a rabbit model. This suggests curcumin is a safe and effective agent for preventing septal perforations.

Area of Science:

  • Otorhinolaryngology
  • Wound Healing Research
  • Pharmacology

Background:

  • Nasal septal perforations can lead to significant morbidity.
  • Current treatments for septal perforations have limitations.
  • Exploring novel therapeutic agents for septal wound healing is crucial.

Purpose of the Study:

  • To investigate the efficacy of intranasal topical curcumin in promoting wound healing of nasal septum perforations.
  • To evaluate curcumin's impact on histological parameters of healing in a rabbit model.

Main Methods:

  • An experimental study was conducted on 14 New Zealand rabbits with surgically created nasal septal perforations.
  • Curcumin or saline (control) was administered intranasally daily for 10 days.
  • Histological analysis assessed epithelial and cartilage regeneration, inflammation, and tissue components.

Main Results:

  • The curcumin group showed significantly enhanced epithelial and cartilage regeneration compared to the control group (P < .05).
  • Significantly higher amounts of collagen and granulation tissue were observed in the curcumin group.
  • No significant differences were noted in other evaluated histological parameters.

Conclusions:

  • Intranasal topical curcumin effectively promotes nasal septum wound healing in an animal model.
  • Curcumin demonstrates potential as a safe and effective medical agent for preventing septal perforations.
Keywords:
Curcuminexperimental studynasal septal perforationnasal septumwound healing

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