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Summary
Urine pH and Eh measurements effectively indicate body changes, unlike stable blood levels. "Chapman's law" states that adverse health effects shift urine pH/Eh from normal, while improvements restore them.
Area of Science:
- Biochemistry
- Physiology
- Analytical Chemistry
Background:
- Graphical methods for pH and Eh relationships in macromolecular systems were previously established.
- In vivo studies require adaptation of existing graphical methods for physiological measurements.
Purpose of the Study:
- To apply graphical methods for representing pH and Eh relationships in vivo.
- To determine the utility of urine and blood measurements as indicators of physiological pH and Eh changes.
Main Methods:
- Application of graphical pH and Eh representation methods to in vivo studies.
- Controlled measurement of urine and blood parameters.
- Analysis of "acid rebound" and phenomena following hyperoxidation.
Main Results:
- Controlled urine measurements are satisfactory indicators of in vivo pH and Eh changes.
- Blood studies show relative constancy, making them less indicative of dynamic changes.
- Two reversing phenomena, "acid rebound" and post-hyperoxidation reduction, were observed, both leading to acidic urine reactions.
Conclusions:
- Urine pH and Eh serve as reliable indicators of physiological shifts.
- "Acid rebound" and post-hyperoxidation reduction are phases of a single phenomenon.
- "Chapman's law" posits that urine pH/Eh deviations from normal reflect unfavorable body conditions, with normalization indicating favorable effects.