Related Experiment Videos
Susceptibility of Pseudomonas aeruginosa strains isolated from hospitalized children
Insights
This study analyzed 1285 Pseudomonas aeruginosa strains from hospitalized children (1981-1984). Many strains showed resistance to common antibiotics, but amikacin, netilmicin, cefsulodin, piperacillin, and azlocillin remained effective.
Area of Science:
- Clinical Microbiology
- Infectious Diseases
- Pediatric Medicine
Background:
- Pseudomonas aeruginosa is a significant opportunistic pathogen in healthcare settings.
- Antibiotic resistance in P. aeruginosa poses a major challenge in treating infections, especially in vulnerable populations like hospitalized children.
Purpose of the Study:
- To investigate the serotype distribution and antibiotic susceptibility patterns of Pseudomonas aeruginosa isolates from hospitalized children.
- To identify effective antimicrobial agents against P. aeruginosa during the 1981-1984 period.
Main Methods:
- Isolation and serotyping of 1285 P. aeruginosa strains from pediatric patients.
- Antimicrobial susceptibility testing against various antibiotic classes, including aminoglycosides and beta-lactams.
Main Results:
- Serotypes O11 and O6, along with nontypable strains, were most prevalent.
- Significant resistance rates to gentamicin and carbenicillin were observed, particularly in serotype O11.
- Amikacin and netilmicin demonstrated high activity among aminoglycosides.
- Cefsulodin, piperacillin, and azlocillin were the most active beta-lactam antibiotics.
Conclusions:
- The study highlights evolving antibiotic resistance in P. aeruginosa within a pediatric hospital setting.
- Specific antibiotics like amikacin, netilmicin, cefsulodin, piperacillin, and azlocillin are recommended for empirical treatment of P. aeruginosa infections in this population.
Abstract:
Pseudomonas aeruginosa strains, 1285 in total, were isolated from hospitalized children in the period 1981-1984. Serotypes 011 and 06 and nontypable strains were the most frequently identified. 44.6% of serotype 011 strains and between 12.4 and 37.7% of other serotypes were resistant to gentamicin, or carbenicillin, or both agents. The aminoglycosides with the highest activity against P. aeruginosa isolates were amikacin and netilmicin. Among the seven beta-lactam antibiotics tested the most active were cefsulodin, piperacillin and azlocillin.