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Adiponectin in Myopathies.

Tania Gamberi1, Francesca Magherini2, Tania Fiaschi3

  • 1Dipartimento di scienze Biomediche, Sperimentali e Cliniche "M. Serio", Università degli studi di Firenze, Viale Morgagni 50, 50134 Firenze, Italy. tania.gamberi@unifi.it.

International Journal of Molecular Sciences
|April 3, 2019
PubMed
Summary
This summary is machine-generated.

Adiponectin, a hormone with diverse roles in skeletal muscle, shows promise for treating myopathies. Lowered adiponectin levels in myopathies suggest hormone replenishment could be a future therapy for muscle degeneration and weakness.

Keywords:
adiponectinmusclemyopathies

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Area of Science:

  • Muscle physiology and endocrinology
  • Neuromuscular pathology research

Background:

  • Adiponectin (APN) plays crucial roles in skeletal muscle, including metabolic, anti-inflammatory, insulin-sensitizing, and regenerative functions.
  • The role of APN in myopathies, a group of neuromuscular disorders causing muscle degeneration and weakness, remains understudied.

Purpose of the Study:

  • To review current knowledge on adiponectin's involvement in various myopathies.
  • To explore the therapeutic potential of adiponectin in treating muscle disorders.

Main Methods:

  • Literature review of studies on adiponectin in hereditary and acquired myopathies.
  • Analysis of findings related to plasma adiponectin concentrations and the effects of hormone replenishment.

Main Results:

  • Some myopathies are associated with reduced plasma adiponectin levels.
  • Adiponectin replenishment demonstrated beneficial effects in preclinical models of diseased muscles.

Conclusions:

  • Adiponectin's altered levels in myopathies highlight its significance in these conditions.
  • Adiponectin represents a potential future therapeutic target for improving myopathy-related abnormalities.