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Vitamin K Dependent Proteins in Kidney Disease
Ciprian N Silaghi1, Tamás Ilyés2, Vladimir P Filip3
1Department of Molecular Sciences, University of Medicine and Pharmacy "Iuliu Hațieganu", 400012 Cluj-Napoca, Romania. silaghi.ciprian@umfcluj.ro.
International Journal of Molecular Sciences
|April 3, 2019
Summary
Patients with chronic kidney disease (CKD) face higher risks of vascular calcification and bone issues. This review explores the role of vitamin K dependent proteins (VKDPs) in CKD, updating knowledge on their connection to kidney disease progression.
Area of Science:
- Nephrology
- Biochemistry
- Vascular Biology
Background:
- Chronic kidney disease (CKD) patients exhibit elevated risks of vascular calcification and impaired bone dynamics, impacting quality of life and survival.
- Vitamin K dependent proteins (VKDPs) are recognized as crucial calcification inhibitors, yet their precise role in CKD pathogenesis remains incompletely understood.
Purpose of the Study:
- To provide an updated review of the relationship between CKD and four key extrahepatic VKDPs: matrix Gla protein, osteocalcin, growth-arrest specific protein 6, and Gla-rich protein.
- To examine the link between CKD and circulating VKDP levels, exploring potential influences of molecular weight, charge, and renal etiology on VKDP modifications within the glomerulus.
Main Methods:
- Systematic literature search of published research from the last ten years.
- Review and synthesis of current knowledge on VKDPs in the context of chronic kidney disease.
Main Results:
- Identified a significant association between CKD and altered levels of circulating VKDPs.
- Highlighted the potential impact of glomerular filtration dynamics (molecular weight, charge) and specific kidney diseases on VKDP status.
Conclusions:
- The interplay between CKD and VKDPs is complex and warrants further investigation.
- This review identifies potential new research avenues concerning VKDPs' function and modification in kidney disease.
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