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Updated: Jan 27, 2026

Generation of Neural Stem Cells from Discarded Human Fetal Cortical Tissue
Published on: May 25, 2011
Spare Parts from Discarded Materials: Fetal Annexes in Regenerative Medicine
Giulia Gaggi1, Pascal Izzicupo2, Andrea Di Credico3
1Department of Medicine and Aging Sciences, University "G. D'Annunzio" of Chieti-Pescara, 66100 Chieti, Italy. giulia.gaggi@unich.it.
Abstract:
One of the main aims in regenerative medicine is to find stem cells that are easy to obtain and are safe and efficient in either an autologous or allogenic host when transplanted. This review provides an overview of the potential use of the fetal annexes in regenerative medicine: we described the formation of the annexes, their immunological features, the new advances in the phenotypical characterization of fetal annexes-derived stem cells, the progressions obtained in the analysis of both their differentiative potential and their secretoma, and finally, the potential use of decellularized fetal membranes. Normally discarded as medical waste, the umbilical cord and perinatal tissue not only represent a rich source of stem cells but can also be used as a scaffold for regenerative medicine, providing a suitable environment for the growth and differentiation of stem cells.
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