Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Olefin Metathesis Polymerization: Ring-Opening Metathesis Polymerization (ROMP)01:16

Olefin Metathesis Polymerization: Ring-Opening Metathesis Polymerization (ROMP)

3.1K
Ring-opening metathesis polymerization or ROMP involves strained cycloalkenes as starting materials. The mechanism of ROMP proceeds by reacting cycloalkene with Grubbs catalyst to give metallacyclobutane intermediate which undergoes a ring-opening reaction to form new carbene. The new carbene reacts with another molecule of cycloalkene. Repetition of these steps leads to the formation of an unsaturated open-chain polymer product. All these steps are reversible, however, relieving the ring...
3.1K
Actin Polymerization01:42

Actin Polymerization

8.4K
Actin polymerization occurs through the head-to-tail association of binding sites on monomeric actin or G-actin to form filamentous or F-actin. The polymerization can be divided into three phases ̶  nucleation, elongation, and steady-state phase.
The nucleation phase involves forming a stable nucleus consisting of three actin monomers to form a new actin filament. Actin-binding proteins such as formins and Arp2/3 complex help filament growth post-nucleation. The Formins form straight...
8.4K
Step-Growth Polymerization: Overview01:03

Step-Growth Polymerization: Overview

4.3K
Step-growth or condensation polymerization is a stepwise reaction of bi or multifunctional monomers to form long-chain polymers. As all the monomers are reactive, most of the monomers are consumed at the early stages of the reaction to form small chains of reactive oligomers, which then combine to form long polymer chains in the late stages. Hence, the reaction has to proceed for a long time to achieve high molecular weight polymers.
Many natural and synthetic polymers are produced by...
4.3K
Olefin Metathesis Polymerization: Overview01:13

Olefin Metathesis Polymerization: Overview

2.6K
Recently, the development of olefin metathesis polymerization advanced the field of polymer synthesis. Simply put, the reorganization of substituents on their double bonds between two olefins in the presence of a catalyst is known as the olefin metathesis reaction. The use of metathesis reaction for polymer synthesis is called olefin metathesis polymerization.
Ruthenium-based Grubbs catalyst is the most commonly used catalyst for olefin metathesis polymerization. Grubbs catalyst consists of a...
2.6K
Actin Polymerization and Cell Motility01:13

Actin Polymerization and Cell Motility

6.6K
Actin is a family of globular proteins that are highly abundant in eukaryotic cells. It makes up approximately 1-5% of total cell protein concentration. Actin monomers polymerize to form a complex network of polarized filaments, the actin cytoskeleton, that plays a crucial role in many cellular processes, including cell motility, division, endocytosis, and metastasis of cancer cells.
Actin cytoskeleton dynamics can produce pushing, pulling, and resistance forces that help the cell to migrate....
6.6K
Radical Chain-Growth Polymerization: Overview01:10

Radical Chain-Growth Polymerization: Overview

3.2K
Chain-growth or addition polymerization is successive addition reactions of monomers with a polymer chain. In radical chain-growth polymerization, the reaction proceeds via a free-radical intermediate. The free radical is formed from radical initiators, which spontaneously generate free radicals by homolytic fission. Organic peroxides (such as dibenzoyl peroxide, as shown in Figure 1) or azo compounds are popular radical initiators. A low concentration ratio of radical initiator to monomer is...
3.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nucleophile-triggered prodrug release from polymer hydrogels.

RSC applied polymers·2025
Same author

Linking Metastatic Potential and Viscoelastic Properties of Breast Cancer Spheroids via Dynamic Compression and Relaxation in Microfluidics.

Advanced healthcare materials·2024
Same author

Interstitial flow potentiates TGF-β/Smad-signaling activity in lung cancer spheroids in a 3D-microfluidic chip.

Lab on a chip·2023
Same author

An Edible Humidity Indicator That Responds to Changes in Humidity Mechanically.

ACS applied polymer materials·2023
Same author

High-throughput mechanophenotyping of multicellular spheroids using a microfluidic micropipette aspiration chip.

Lab on a chip·2023
Same author

A nano-fibrous platform of copolymer patterned surfaces for controlled cell alignment.

RSC advances·2022

Related Experiment Video

Updated: Jan 27, 2026

Preparation of Silicon Nanowire Field-effect Transistor for Chemical and Biosensing Applications
11:25

Preparation of Silicon Nanowire Field-effect Transistor for Chemical and Biosensing Applications

Published on: April 21, 2016

11.6K

Polymeric Nanowires for Diagnostic Applications.

Hendrik Hubbe1, Eduardo Mendes2, Pouyan E Boukany3

  • 1Department of Chemical Engineering, Delft University of Technology, Van der Maasweg 9, 2629HZ Delft, The Netherlands. h.m.k.hubbe@tudelft.nl.

Micromachines
|April 3, 2019
PubMed
Summary
This summary is machine-generated.

Polymer nanowires show promise for biosensing devices. This review covers fabrication, alignment, and detection methods for creating effective nanowire sensors for biomolecules.

Keywords:
Affordable biosensorbio-diagnosticsbio-microfluidicsbioelectronicsbiosensorpolymeric nanowire

More Related Videos

Microfluidic Applications for Disposable Diagnostics
10:21

Microfluidic Applications for Disposable Diagnostics

Published on: February 3, 2008

9.3K
Photogeneration of N-Heterocyclic Carbenes: Application in Photoinduced Ring-Opening Metathesis Polymerization
12:19

Photogeneration of N-Heterocyclic Carbenes: Application in Photoinduced Ring-Opening Metathesis Polymerization

Published on: November 29, 2018

9.0K

Related Experiment Videos

Last Updated: Jan 27, 2026

Preparation of Silicon Nanowire Field-effect Transistor for Chemical and Biosensing Applications
11:25

Preparation of Silicon Nanowire Field-effect Transistor for Chemical and Biosensing Applications

Published on: April 21, 2016

11.6K
Microfluidic Applications for Disposable Diagnostics
10:21

Microfluidic Applications for Disposable Diagnostics

Published on: February 3, 2008

9.3K
Photogeneration of N-Heterocyclic Carbenes: Application in Photoinduced Ring-Opening Metathesis Polymerization
12:19

Photogeneration of N-Heterocyclic Carbenes: Application in Photoinduced Ring-Opening Metathesis Polymerization

Published on: November 29, 2018

9.0K

Area of Science:

  • Materials Science
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Polymer nanowire research has advanced significantly.
  • Diverse materials and chemical modifications enable functional biosensing applications.

Purpose of the Study:

  • To review polymer nanowire fabrication and materials for biosensor development.
  • To discuss alignment methods for single-wire configurations crucial for electrical readout.

Main Methods:

  • Literature review of publications on polymer nanowires for biomolecule sensing.
  • Analysis of fabrication techniques and their impact on nanowire alignment.
  • Evaluation of alignment strategies for achieving desired single-wire configurations.

Main Results:

  • Various polymer nanowire fabrication methods exist, yielding different structural outcomes.
  • Alignment is critical for single-wire configurations needed for electrical signal detection.
  • Some methods inherently produce aligned nanowires, while others require post-fabrication manipulation.

Conclusions:

  • Polymer nanowires are versatile for diagnostic biosensing.
  • Optimized fabrication and alignment are key to developing effective nanowire-based biosensors for biomolecule detection.