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Live-Cell Imaging Assays to Study Glioblastoma Brain Tumor Stem Cell Migration and Invasion
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The Role of SVZ Stem Cells in Glioblastoma

Christine Altmann1, Stefanie Keller2, Mirko H H Schmidt3,4,5

  • 1Institute for Microscopic Anatomy and Neurobiology, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, Germany. Christine.Altmann@unimedizin-mainz.de.

Cancers
|April 3, 2019
PubMed

Insights

Glioblastoma, a common brain cancer, is poorly understood. Identifying neural stem cells (NSCs) as a potential origin may lead to new glioblastoma treatments.

Area of Science:

  • Neuro-oncology
  • Cancer Stem Cell Biology
  • Adult Neurogenesis

Background:

  • Glioblastoma is the most common and aggressive primary brain cancer in adults.
  • Despite extensive research, glioblastoma remains poorly understood due to its genetic and transcriptional heterogeneity.
  • Conventional therapies have shown limited success, leading to poor patient survival rates.

Purpose of the Study:

  • To explore the link between neural stem cells (NSCs) and glioblastoma cancer stem cells (CSCs).
  • To identify potential cells of origin for glioblastoma to improve therapeutic strategies.
  • To review current therapeutic approaches targeting the cell of origin in glioblastoma.

Main Methods:

  • Literature review of current findings on NSCs and glioblastoma CSCs.
  • Analysis of the role of the subventricular zone as a niche for NSCs.
  • Discussion of therapeutic strategies based on cell of origin identification.

Main Results:

  • Neural stem cells (NSCs) in the subventricular zone possess self-renewal and proliferation capacities.
  • NSCs can differentiate into neuronal and glial progenitor cells.
  • Evidence suggests a potential link between NSCs and the origin of glioblastoma.

Conclusions:

  • Identifying the cell of origin in glioblastoma is crucial for improving clinical outcomes.
  • Neural stem cells are a promising candidate for the origin of glioblastoma.
  • Targeting glioblastoma CSCs derived from NSCs may offer novel therapeutic avenues.
Keywords:
brain tumor stem cellsglioblastomaneural stem cellsneurogenesissubventricular zonetherapy

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