Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Animal Mitochondrial Genetics02:59

Animal Mitochondrial Genetics

9.0K
Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
9.0K
Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes02:16

Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes

15.7K
The present-day mitochondrial and chloroplast genomes have retained some of the characteristics of their ancestral prokaryotes and also have acquired new attributes during their evolution within eukaryotic cells. Like prokaryotic genomes, mitochondrial and chloroplast genomes neither bind with histone-like proteins nor show complex packaging into chromosome-like structures, as observed in eukaryotes. Unlike mitotic cell divisions observed in eukaryotic cells, mitochondria and chloroplasts...
15.7K
Export of Mitochondrial and Chloroplast Genes02:19

Export of Mitochondrial and Chloroplast Genes

4.1K
A eukaryotic cell can have up to three different types of genetic systems: nuclear, mitochondrial, and chloroplast. During evolution, organelles have exported many genes to the nucleus; this transfer is still ongoing in some plant species. Approximately 18% of the Arabidopsis thaliana nuclear genome is thought to be derived from the chloroplast’s cyanobacterial ancestor, and around 75% of the yeast genome derived from the mitochondria’s bacterial ancestor. This export has occurred...
4.1K
What is Genetic Engineering?00:49

What is Genetic Engineering?

80.0K
Overview
80.0K
Resistivity01:22

Resistivity

4.4K
When a voltage is applied to a conductor, an electrical field is generated, and charges in the conductor feel the force due to the electrical field. The current density that results depends on the electrical field and the properties of the material. In some materials, including metals at a given temperature, the current density is approximately proportional to the electrical field. In these cases, the current density can be modeled as:
4.4K
Resistance01:19

Resistance

5.7K
When a current moves through any conductor, the conductor causes some level of difficulty for the current to flow. The measure of that difficulty is known as the resistance of the material and is represented by R. Every material has its own resistance. In the case of conductors, heat is emitted whenever a current passes through them. Resistance depends on the resistivity of the material. Resistivity is a characteristic of the material used to fabricate electrical components, whereas the...
5.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A microenvironment-adaptive bilayer composite dressing for disrupting MRSA biofilms and promoting wound regeneration via ROS-mediated immune regulation.

Bioactive materials·2026
Same author

Enzyme-responsive hydrogel coating for <i>in situ</i> re-endothelialization of bioprosthetic heart valves.

Theranostics·2026
Same author

An antioxidant and injectable hydrogel dressing for repairing MRSA biofilm-infected diabetic wounds.

Journal of nanobiotechnology·2026
Same author

Linking ecological strategies to niche breadth: interpretable machine learning unravels community patterns of nirS-type aerobic denitrifiers along oxygen gradients in drinking water reservoirs.

Water research·2026
Same author

Genetically engineered cellular membrane-camouflaged nanoparticles amplify immune response against recurrent metastatic triple-negative breast cancer.

Biomaterials·2026
Same author

Rainstorm regimes modulate cyanobacterial bloom dynamics in deep reservoirs: Synergistic effects of nutrient pulses and hydrological perturbations.

Limnology and oceanography·2026

Related Experiment Video

Updated: Jan 27, 2026

In Vivo Investigation of Antimicrobial Blue Light Therapy for Multidrug-resistant Acinetobacter baumannii Burn Infections Using Bioluminescence Imaging
09:29

In Vivo Investigation of Antimicrobial Blue Light Therapy for Multidrug-resistant Acinetobacter baumannii Burn Infections Using Bioluminescence Imaging

Published on: April 28, 2017

9.9K

Mitochondrial Surface Engineering for Multidrug Resistance Reversal.

Wei Chen1, Kun Shi1, Bingyang Chu1

  • 1State Key Laboratory of Biotherapy and Cancer Center, West China Hospital , Sichuan University and Collaborative Innovation Center for Biotherapy , Chengdu 610041 , People's Republic of China.

Nano Letters
|April 3, 2019
PubMed
Summary

This study introduces a novel nanomaterial-coated mitochondria complex to overcome multidrug resistance (MDR) in cancer. The complex delivers siRNA and mitochondria to reduce drug resistance and enhance chemotherapy effectiveness.

Keywords:
MDR reversalMitochondrial dysfunctionRNA interferencelayer-by-layer assemblyorganelle transplantation

More Related Videos

The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis
23:06

The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis

Published on: August 11, 2008

19.6K
Protein Engineering by Yeast Surface Display
05:49

Protein Engineering by Yeast Surface Display

Published on: November 29, 2024

3.5K

Related Experiment Videos

Last Updated: Jan 27, 2026

In Vivo Investigation of Antimicrobial Blue Light Therapy for Multidrug-resistant Acinetobacter baumannii Burn Infections Using Bioluminescence Imaging
09:29

In Vivo Investigation of Antimicrobial Blue Light Therapy for Multidrug-resistant Acinetobacter baumannii Burn Infections Using Bioluminescence Imaging

Published on: April 28, 2017

9.9K
The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis
23:06

The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis

Published on: August 11, 2008

19.6K
Protein Engineering by Yeast Surface Display
05:49

Protein Engineering by Yeast Surface Display

Published on: November 29, 2024

3.5K

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Cancer Research

Background:

  • Multidrug resistance (MDR) significantly limits chemotherapy efficacy.
  • MDR involves both pump and non-pump resistance mechanisms, reducing drug accumulation and potency.
  • Overcoming MDR requires strategies that address both resistance pathways simultaneously.

Purpose of the Study:

  • To develop a novel nanomaterial-coated mitochondria complex for overcoming MDR.
  • To effectively deliver small interfering RNA (siRNA) and mitochondria into multidrug-resistant cancer cells.
  • To concurrently target pump resistance and restore cellular metabolism to reverse MDR.

Main Methods:

  • Development of a unique organelle-material complex integrating siRNA and mitochondria.
  • Utilizing nanomaterial coating to facilitate delivery and overcome cellular barriers.
  • Employing functional siRNA to down-regulate pump resistance proteins.
  • Transplanting mitochondria to restore intracellular metabolism and enhance apoptosis.

Main Results:

  • The developed complex successfully delivered siRNA and mitochondria into MDR cells.
  • Functional siRNA effectively reduced pump resistance-related proteins.
  • Transplanted mitochondria improved apoptotic signaling by restoring metabolic environment.
  • The combined approach demonstrated potential for reversing overall MDR.

Conclusions:

  • The novel organelle-material complex offers a promising strategy to combat MDR in cancer chemotherapy.
  • High spatial-temporal synchronization of synthetic and living components is key to reversing MDR.
  • This approach holds potential for enhancing anticancer drug efficacy by overcoming resistance mechanisms.