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Related Experiment Video

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Author Spotlight: Advancing Understanding of Age-Related Lens Stiffness Changes

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Three-tier testing approach for optimal ocular tolerance sunscreen.

Mridvika Narda¹, David Ramos-Lopez¹, Greg Mun²

¹a Innovation and Development, ISDIN SA , Barcelona , Spain.

Cutaneous and Ocular Toxicology

|April 3, 2019

Summary

This study evaluated a new facial sunscreen's ocular tolerance using a three-tiered approach. The water-based sunscreen demonstrated good eye safety, comparable to baby shampoo, suggesting it is well-tolerated for ocular use.

Keywords:

EpiOcular™Sunscreen TRPV1 receptors eye stinging potential instillation ocular tolerability

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Area of Science:

Ophthalmology
Dermatology
Toxicology

Background:

Poor ocular tolerance of sunscreens leads to low compliance.
A novel three-tiered testing strategy was developed for ocular tolerance assessment.
This strategy includes in vitro irritation, in vitro pain receptor activation, and in vivo clinical studies.

Purpose of the Study:

To evaluate the ocular tolerance of a new water-based facial sunscreen (SCFW).
To validate a three-tiered approach for assessing sunscreen ocular tolerability.

Main Methods:

Tier 1: In vitro EpiOcular™ assay for ocular irritation potential.
Tier 2: In vitro NociOcular assay to measure TRPV1 activation (pain receptor potential).
Tier 3: In vivo clinical study involving ocular instillation and ophthalmologic evaluation.

Main Results:

SCFW showed minimal cytotoxicity in the EpiOcular™ assay, indicating low irritation potential.
SCFW exhibited minimal TRPV1 activation in the NociOcular assay, suggesting low sting potential.
Clinical study results demonstrated ocular tolerability comparable to 10% baby shampoo.

Conclusions:

SCFW possesses negligible ocular irritation and minimal pain receptor activation potential.
The new facial sunscreen exhibits good ocular tolerability, similar to a mild control.
The described tiered approach effectively evaluates ocular tolerability for facial sunscreens.